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CRK — MAPK14

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Van Wagoner et al., J Neurochem 2000 (Astrocytoma) : Finally, we show that the MAPKs ERK1/2 and p38 are activated by OSM in astrocytes and that this activation is reduced by the MAPK inhibitors
Mackova et al., Endocrinology 2000 : Furthermore, inhibition of p42/44MAPK phosphorylation had no effect on p38MAPK activation
Nelson et al., J Biol Chem 2001 : These data indicate that suppression of Akt and MAPK in the presence of activated p38 results in cell death and a possible mechanism for the enhanced apoptosis produced by the combination of CI-1033 and gemcitabine in MDA-MB-453 cells
Choi et al., Cancer Res 2001 (Glioblastoma...) : Herein, we demonstrate that : ( a ) stimulation with agonistic anti-Fas monoclonal antibody CH-11 and human recombinant soluble Fas ligand induces expression of the CC chemokine MCP-1 and the CXC chemokine interleukin-8 by human glioma cell lines at the mRNA and protein levels in a dose- and time dependent manner ; ( b ) selective pharmacological inhibitors of MEK1 ( U0126 and PD98059 ) and p38 mitogen activated protein kinase ( MAPK ) ( SB202190 ) suppress Fas mediated chemokine expression in a dose dependent manner ; ( c ) Fas ligation on human glioma cells leads to activation of both extracellular signal regulated kinases ERK1/ERK2 and p38 MAPK ; and ( d ) GBM samples express higher levels of Fas compared with normal control brain, which correlates with increased interleukin 8 expression
Kumar et al., J Cell Physiol 2001 (Bone Resorption) : In addition, IL-1 and TNF also activated p38 MAPK in fetal rat long bones and p38 MAPK inhibitors inhibited IL-1- and TNF stimulated bone resorption in vitro in a dose dependent manner ( IC ( 50 ) s 0.3 -- 1 microM )
Canesi et al., Gen Comp Endocrinol 2001 : Moreover, both zinc and insulin induced activation of mitogen activated protein kinases ( MAPKs ) ; however, whereas zinc gave a clear effect on the stress activated p-38 MAPK, insulin activated extracellular activated MAPK ( ERK2 ) and inhibited p-38
Forsberg et al., Immunology 2001 : Taken together, these results showed that TNF-alpha potentiates the CR3 mediated respiratory burst in neutrophils not only by triggering a p38 MAPK dependent up-regulation of CD11b/CD18 but also by modulating the signalling pathways
Park et al., J Leukoc Biol 2002 : Thus, the results of this work suggest that p43 should induce cell-cell adhesion via the PI3-K/ERK- and p38 MAPK dependent up-regulation of ICAM-1
Takauji et al., J Leukoc Biol 2002 : These results suggest that CpG DNA induces p38 MAPK dependent phosphorylation of STAT1 in a manner independent of IFN-alpha/beta, which may cause ISGF3 formation to increase the transcription of the IRF-7 gene, thereby leading to IFN-alpha production in human PDC
Horowitz et al., J Biol Chem 2004 : Conditioned medium from TGF-beta1 treated cells rapidly induces PKB/Akt activation in an SB203580- and suramin-sensitive manner, suggesting p38 MAPK dependent production of a secreted growth factor that activates this pro-survival pathway by an autocrine/paracrine mechanism
Lüschen et al., Exp Cell Res 2004 : Finally, we demonstrate that the nuclear factor kappaB (NF-kappaB) dependent gene expression, shown as an example for the anti-apoptotic gene cellular inhibitor of apoptosis ( c-IAP2 ), was reduced by p38 MAPK inhibition
Chio et al., Cell Signal 2004 : Via PKA, PKC and p38 MAPK dependent signals, dBcAMP also induced inhibitory subunit of NF-kappaB ( IkappaB ) degradation, IkappaB kinase (IKK) activation, nuclear translocation of NF-kappaB subunit p65 and its association with the CREB binding protein (CBP)
Brown et al., J Biol Chem 2004 : We further report that incubation of neutrophils with TNFalpha results in the p38 MAPK dependent phosphorylation of a subpopulation of p47(phox) and p67(phox) molecules, whereas PAF priming results in phosphorylation only of p67(phox)
Hernandez et al., Diabetologia 2004 (Insulin Resistance) : Since treatment with TNF-alpha activates stress kinases, including c-jun NH2 terminal kinase ( JNK ), and p42/p44 and p38 mitogen activated protein kinases ( MAPK ), we explored the contribution of these pathways to insulin resistance by TNF-alpha
Mori et al., Cancer Res 2004 (Cell Transformation, Neoplastic...) : In parallel, p38 mitogen activated protein kinase and extracellular signal regulated kinase 1/2 were activated , which contributed to the induction of MMP-13, and a glutathione S-transferase pull-down assay showed the activation of a small GTPase, Rac1
Alvarado-Kristensson et al., J Biol Chem 2005 : Consequently, the early and temporary activation of PP2A in neutrophils impaired not only the p38 MAPK mediated inhibition of caspase 3 but also restored the activity to caspase 3 that had already been phosphorylated and thereby inactivated
Chen et al., Zhonghua Shao Shang Za Zhi 2004 (Acute Lung Injury...) : AP-1 might mediate the production of proinflammatory factors, such as TNF-alpha and IL-1beta in lungs leading to pulmonary vascular endothelial injury, after being activated by activated p38 MAPK
Studer et al., J Orthop Res 2005 : TGF-beta stimulated proteoglycan synthesis was decreased by p38 MAPK inhibition , however COX2 inhibition restored the response to TGF-beta in IL-1 activated cells
Into et al., Cell Microbiol 2005 : MLP- or PGN induced cell death reactions, including DNA fragmentation and caspase-3/7 activation, were also down-regulated by the ASK1 mutant via p38 MAPK inhibition
Singh et al., Neuroscience 2005 (Nerve Degeneration) : Alternatively, gp120 induced increases in caspase-3 activity, neurite losses and neuronal death were prevented by p38 , but not c-jun-N-terminal kinase, mitogen activated protein kinase inhibition
Ahmed et al., J Nutr 2005 : IL-1beta induced phosphorylation of p38-MAPK , but not that of c-Jun-N-terminal kinase or extracellular regulated kinase, was most susceptible to inhibition by low doses of PFE, and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay
Jacquel et al., Oncogene 2006 (Leukemia) : Differentiation of K562 cells by the combination of PMA and SB required Erk1/2 activation, a threshold of JNK activation and p38 MAPK inhibition
Zhang et al., Asian J Androl 2006 (Cryptorchidism...) : To assess the spatiotemporal changes in the expression of extracellular signal regulated kinases 1 and 2 ( ERK1/2 ), c-Jun N-terminal kinases (JNK) and p38 mitogen activated protein kinases ( MAPK ) in response to heat stress in the cryptorchid testis, and to investigate a possible relation to Sertoli cell dedifferentiation
Ho et al., Mol Cell Endocrinol 2006 : Studies with selective MAPK inhibitors reveal a modulating effect of MAPKs on arylalkylamine-N-acetyltransferse ( AA-NAT ) activity, with involvement of p42/44MAPK in the induction of AA-NAT and p38MAPK participating in the amplitude and duration of the AA-NAT response
De Chiara et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Furthermore, we obtained evidence that p38 MAPK induced Bcl-2 phosphorylation plays a key role in the early events following serum deprivation in embryonic fibroblasts
Hu et al., J Biol Chem 2006 (MAP Kinase Signaling System) : Akt2 inhibition blocked ezrin but not p38 MAPK or MAPKAPK-2 phosphorylation, suggesting that MAPKAPK-2 could be an intermediate in p38 MAPK dependent Akt2 activation
Rahman et al., J Immunol 2006 (Asthma...) : IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells : role of MAPK ( Erk1/2, JNK, and p38 ) pathways
Brault et al., Am J Physiol Regul Integr Comp Physiol 2007 : LPA decreased intracellular GSH levels and induced a p38 MAPK/JNK dependent inducible nitric oxide synthase (NOS) expression
Han et al., J Cell Physiol 2007 : ANG II-induced increase in [ ( 3 ) H ] thymidine incorporation was blocked by the inhibition of p44/42 MAPKs but not by p38 MAPK inhibition
Moeinpour et al., Mol Immunol 2007 (Hemorrhage...) : Trauma-hemorrhage increased the production of IL-6, IL-10, IL-12 and TNF-alpha enhanced the expression of TLR4, MyD88 as well as the activation of MAPK proteins ( p38 , ERK and JNK ) in epidermal keratinocytes
Wang et al., J Mol Cell Cardiol 2007 : The release of VEGF was analyzed by using MSC conditioned media under hypoxia or TNF stimulation with or without p38 MAPK inhibition
Pedersen et al., Cell Physiol Biochem 2007 (Carcinoma, Ehrlich Tumor) : Long-term shrinkage elicited caspase-3 activation and a loss of cell viability, which was augmented by ERK1/2 or JNK1/2 inhibition, and attenuated by p38 MAPK inhibition
Huh et al., Int Immunopharmacol 2007 (MAP Kinase Signaling System) : Prodigiosin blocked phosphorylation of p38 mitogen activated protein kinase ( MAPK ) and c-Jun NH ( 2 ) -terminal kinase ( JNK ), but not that of extracellular signal regulated kinase 1/2 ( ERK 1/2 )
Studer et al., Spine (Phila Pa 1976) 2007 (Spinal Diseases) : Nucleus pulposus cells in alginate bead culture were exposed to IL-1 or TNF-alpha, with or without p38 MAPK inhibition , and conditioned media analyzed for accumulation of nitric oxide ( NO ), prostaglandin E2 ( PGE2 ), IL-6, matrix metalloproteinase-3 (MMP-3), and tissue inhibitor of matrix metalloproteinase-1 ( TIMP-1 ) through 10 days
Jarnicki et al., J Immunol 2008 (MAP Kinase Signaling System...) : We found that TLR ligands also promote the induction of IL-10 secreting regulatory T ( Treg ) cells through p38 MAPK induced IL-10 production by dendritic cells ( DC )
Kang et al., J Cell Physiol 2008 (Uterine Cervical Neoplasms) : The As2O3 induced Bcl-2 phosphorylation was attenuated largely by JNK inhibition using SP600125 or si-JNK and to some extent by p38 MAPK inhibition with PD169316 or si-p38 MAPK
Prickett et al., J Biol Chem 2008 : TAB4 mutated at Phe-Pro dominantly interfered with IL-1beta activation of NF-kappaB involving IKK dependent but not p38 MAPK dependent signaling
Takahashi et al., J Endocrinol 2008 : Estradiol rapidly activated MAPK phosphorylation including extracellular signal regulated kinase 1/2, p38, and stress activated protein kinase/c-Jun NH2-terminal kinase pathways and BMP6, BMP7, and activin preferentially inhibited estradiol induced p38 phosphorylation
Wu et al., Free Radic Biol Med 2009 (MAP Kinase Signaling System) : Activation of JNK and p38MAPK was weaker in TNFalpha plus PY-treated NOS2 ( -/- ) mice and 1400W and NAC blocked the activation of JNK and p38MAPK in wild-type mice
Khandrika et al., Oncogene 2009 (Prostatic Neoplasms) : Hypoxia associated p38 mitogen activated protein kinase mediated androgen receptor activation and increased HIF-1alpha levels contribute to emergence of an aggressive phenotype in prostate cancer
Kulasekaran et al., Am J Respir Cell Mol Biol 2009 (Idiopathic Pulmonary Fibrosis) : TGF-beta1 has been shown to attenuate myofibroblast apoptosis through the p38 MAPK dependent secretion of a soluble factor, which activates PI3K/AKT
Sheng et al., J Neuroimmune Pharmacol 2009 (MAP Kinase Signaling System) : IL-1beta triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways, but WIN55,212-2 mainly inhibited p38 MAPK phosphorylation
Kim et al., Tissue Eng Part A 2009 : These findings reveal that BEC is involved in the osteoblast differentiation of hMSCs through enhancement of cell proliferation and modulation of the local endocrine environment through VEGF and BMP-2 induction through the activation of MAPK ( Erk and p38 ) and the calcium channel
Wen et al., Leuk Res 2010 (Multiple Myeloma) : Furthermore, the synergistically potentiated apoptosis by p38 MAPK inhibition was associated with the attenuation of ATO+bortezomib mediated activation of Hsp27 as well as the enhancement of ATO+bortezomib mediated JNK activation, p53 up-regulation, and Bcl-2 down-regulation
Iorns et al., Carcinogenesis 2009 (Breast Neoplasms) : This study identifies a novel role for CRK7 in MAPK regulation and resistance to estrogen signaling inhibitors
Yao et al., Am J Chin Med 2009 (MAP Kinase Signaling System) : Moreover, magnolol attenuated the deactivation of ERK/MAPK ( extracellular signal regulated kinase/mitogen activated protein kinase ) and the enhanced activation of p38 , JNK ( c-Jun N-terminal kinase ) induced by H2O2
Dumka et al., Leukemia & lymphoma 2009 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : p38 MAPK inhibition also reversed dasatinib induced suppression of CML patient derived leukemic colony forming units progenitor growth in vitro, as well as BCR/ABL expressing KT-1 cell derived leukemic progenitor growth
Watanabe et al., Mol Cancer Res 2009 (Sarcoma, Synovial) : Adaptor protein Crk induces Src dependent activation of p38 MAPK in regulation of synovial sarcoma cell proliferation ... Crk also induced the phosphorylation of p38 MAPK , and SB203580, a p38 MAPK-specific inhibitor, increased expression of p16(INK4A) gene in SYO-1 cells
Mukhopadhyay et al., Cardiovasc Res 2010 (Cardiomyopathies...) : Remarkably, cell death and MAPK activation induced by AEA, HU210, and DOX +/- AEA/HU210 were largely attenuated by either CB1 antagonists ( rimonabant and AM281 ) or by inhibitors of p38 and JNK MAPKs
Morris et al., Toxicol Pathol 2010 (Gastrointestinal Diseases...) : Similar effects were observed following exposure to inhibitors of MAPK activated protein kinase-2 (MK2), further implicating the role of p38alpha MAPK signaling pathway inhibition in these effects
Cheng et al., J Immunol 2010 : Inhibition of p38 MAPK had a similar effect on adhesion molecule expression, and p38 MAPK activation was reduced in MIF-deficient HUVECs, suggesting that MIF mediated these effects via promotion of p38 MAPK activation
Zhu et al., Biol Psychiatry 2010 (Disease Models, Animal) : Our studies identify IL-1R- and p38 MAPK dependent regulation of SERT as one of the mechanisms by which environmentally driven immune system activation can trigger despair-like behavior in an animal model, encouraging future analysis of the pathway for risk factors in neuropsychiatric disorders
Brighton et al., Br J Pharmacol 2011 (MAP Kinase Signaling System) : Conversely, depletion of arrestin3 enhanced p38 signals to each agonist, whilst arrestin2 suppression increased oxytocin-, but not histamine induced p38 MAPK responses
Yeh et al., Differentiation 2012 : Immunoblot analysis revealed early ( 1h ) activation of the mitogen activated protein kinase ( MAPK) ERK1/2, and progressive activation of epidermal growth factor receptor (EGFR), p38MAPK and p70S6 kinase (p70S6K) during 72h of isoproterenol treatment
Anur et al., Blood 2012 (Disease Models, Animal...) : Low doses ( 50nM ) of both agents inhibited p38 MAPK dependent activation of MAPKAPK2 (MK2) and suppressed MK2 dependent TNFa production without substantially influencing TNFa gene transcription
Liu et al., Glia 2012 (Alzheimer Disease) : Our data suggest that activation of astrocytes PP2A in tg2567 mice may stimulate the migration of astrocytes to the amyloid plaques by p38 MAPK inhibition , implying that PP2A deficits observed in AD may cause Aß accumulation via hindering the astrocytes migration
Lacerda et al., PloS one 2012 : All of the novel synthesized compounds described in this study were evaluated for their in vitro capacity to inhibit tumor necrosis factor a ( TNF-a production in cultured macrophages ) and in vitro MAPK p38a inhibition
Slawinska-Brych et al., Leuk Res 2013 (Multiple Myeloma) : Induction of apoptosis in multiple myeloma cells by a statin-thalidomide combination can be enhanced by p38 MAPK inhibition
Limper et al., J Pharm Pharmacol 2013 : Distinct compounds caused a strong inhibition of MAPK/ERK kinase (MEK) phosphorylation, weak effects on extracellular-signal regulated kinase ( ERK ) phosphorylation and no significant effect on p38 and c-Jun amino-terminal kinase
Liu et al., Mol Cell Biol 1998 (Cell Transformation, Neoplastic) : Expression of WT-PTP1B reduces formation of p130Cas-Crk complexes and inhibits mitogen activated protein kinase activation by Src and Crk