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CDKN1A — HIF1A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CDKN1A → Complex of HIF1A-MYC (increases)
  Evidence: a study using HCT116 colon carcinoma cells depleted of either p53 or p21 found that HIF1? is required for cellcycle arrest through the induction of p21 by a direct interaction between HIF1? and MYC39.

Text-mined interactions from Literome

Koshiji et al., Cell cycle (Georgetown, Tex.) 2004 : We recently demonstrated that the G ( 1 ) checkpoint gene p21 ( cip1 ) is activated by HIF-1alpha with a novel mechanism that involves the HIF-1alpha PAS domains to displace Myc binding from p21 ( cip1 ) promoter
Mack et al., Mol Cell Biol 2005 (Fibrosarcoma) : Gene silencing of HIF-1alpha by small interfering RNA reduced p21 and p27 protein and mRNA levels in Vhl ( - ) ( / ) ( - ) MEFs
Mizokami et al., World journal of surgical oncology 2006 : These results suggest that loss of HIF-1alpha dependent p21 expression results in decreased apoptosis, increased cell survival and more aggressive tumors
Rohwer et al., PloS one 2010 (Stomach Neoplasms) : HIF-1alpha markedly suppressed chemotherapy induced activation of p53 and p21 as well as the retinoblastoma protein, eventually resulting in cell cycle arrest