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CD46 — IL12A

Text-mined interactions from Literome

Karp et al., Immunol Rev 1999 (Measles) : CD46 mediated downregulation of IL-12 has turned out to be a specific instance of a more general pattern of tight inhibitory control over IL-12 production effected by complement and phagocytic receptors on antigen presenting cells
Wang et al., J Immunol 2000 : That is, binding of MCP on human monocytes by measles virus hemagglutinin or cross linking by an anti-MCP Ab resulted in IL-12 down-regulation, while binding to MCP by Neisseria on epithelial cells produced a calcium flux
Jones et al., J Immunol 2009 : Neither the genetic absence of IL-4, IL-4Ralpha chain, STAT-6, IFN-gamma, or IL-12p40 nor mAb blockade of IFN-gamma, IL-3, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17A, IL-12p40, or IL-12p40Rbeta1 before Ag challenge in WT mice reduces the pulmonary MCp increase
Karp et al., Science 1996 : Cross linking of CD46 , a complement regulatory protein that is the cellular receptor for MV, with antibody or with the complement activation product C3b similarly inhibited monocyte IL-12 production, providing a plausible mechanism for MV-induced immunosuppression
Chensue et al., J Immunol 1996 (Granuloma) : In addition, MCP-1 inhibited IL-12 production by inflammatory macrophages