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CD28 — IL22
Text-mined interactions from Literome
Okkenhaug et al., Nat Immunol 2001
:
Nonetheless, this mutated form of
CD28 still prevents the induction of anergy and
promotes T cell proliferation,
interleukin 2 secretion and B cell help
Goto et al., Cell Immunol 2009
:
Treatment with IL-6/TGF-beta decreased
CD3/CD28 stimulated production of
IL-22 , but not that of IL-17, in NKT cells
Wong et al., Immunol Invest 2009
(Asthma) :
The number of peripheral Th17 lymphocytes, expression of CCR6 on Th cells, and ex vivo IL-23, anti-CD3 and
anti-CD28 induced production of
IL-22 by PBMC were significantly elevated in asthmatic patients compared with control subjects ( all p < 0.01 )
Abreu et al., Arthritis Res Ther 2010
(Arthritis, Experimental...) :
Ex vivo, Rac1 inhibitory peptide suppressed T-cell
receptor/CD28 dependent production of tumor necrosis factor alpha, interferon gamma and
interleukin-17 by T cells from collagen primed mice, and reduced induction of ICOS and CD154, T-cell costimulatory proteins important for B-cell help