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AKT1 — CD19

Pathways - manually collected, often from reviews:

• NCI Pathway Database BCR signaling pathway: PI3K/BCAP/CD19 complex (CD19-PIK3CA-PIK3R1) → AKT1 (AKT1) (modification, activates) Inabe et al., Blood 2002*

Text-mined interactions from Literome

Otero et al., J Biol Chem 2001 (Lymphoma, B-Cell) : Using CD19-deficient B-lymphoma cells and mouse splenic B-cells, we show that CD19 is necessary for efficient activation of Akt following cross linking of surface immunoglobulin or Igbeta
Inabe et al., Blood 2002 : Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement
Johnson et al., J Immunol 2008 : IL-7 stimulation of rested CD19 ( + ) cells resulted in robust induction of p-ERK1/2, but no induction of AKT enzymatic activity
Dasu et al., Mol Immunol 2009 : BCR and CD19 co-cross linking activates Akt , a key mediator of survival and proliferation signals downstream of PI3K in splenic B-2 cells