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CA2 — EPO

Text-mined interactions from Literome

Metzen et al., J Physiol 1999 (Carcinoma, Hepatocellular...) : In the presence of extracellular Ca2+ the membrane permeant calcium chelator BAPTA-AM stimulated the production of EPO ( P < 0.05 ) but not of VEGF while EGTA-AM, a closely related agent, affected neither EPO nor VEGF formation under these conditions
Kuramochi et al., Eur J Biochem 1990 : When the effect of erythropoietin and Me2SO on the intracellular Ca2+ level was examined using fura 2, no acute change was observed
Lawrence et al., J Clin Invest 1987 : Using the rabbit reticulocyte membrane as a model of the immature red cell membrane, we investigated the effects of human recombinant erythropoietin on membrane Ca2+-ATPase ( calcium pump ) activity in vitro ... Ca2+-ATPase activity of membranes prepared from rabbit mature red blood cells was not inhibited by erythropoietin ... The novel effect of erythropoietin on reticulocyte membrane Ca2+-ATPase activity is a mechanism by which erythropoietin can influence cellular Ca2+ metabolism
Vaziri et al., Am J Physiol 1995 : In the present study we examined the effects of EPO and the vehicle alone on rat caudal artery contractile response and basal and thrombin stimulated platelet cytosolic Ca2+ concentration ([Ca2+]i) in vitro and on blood pressure ( BP ) and heart rate in vivo
Schaefer et al., J Biol Chem 1996 (Leukemia, Erythroblastic, Acute) : In addition, no increase in [ Ca2+ ] i was observed in ELM-I-1 cells in response to erythropoietin
Cheung et al., Blood 1997 : Erythropoietin (Epo) induces a dose dependent increase in intracellular free Ca2+ ( [ Ca2+ ] i ) in human erythroblasts, which is dependent on extracellular Ca2+ and blocked by high doses of nifedipine or Ni2+ ... To minimize washout of cytosolic constituents, we next used nystatin perforated patch, but did not find any Epo induced whole cell Ca2+ current
Schaefer et al., Cell Signal 1997 : There are many open questions including the role of Ca2+ in erythropoietin induced signal transduction