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AKT1 — BRCA1

Pathways - manually collected, often from reviews:

• WikiPathways Hepatitis C and Hepatocellular Carcinoma: AKT1 → BRCA1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: AKT1 — BRCA1 (direct interaction, pull down) Xiang et al., Oncogene 2011*
• IRef Biogrid Interaction: AKT1 — BRCA1 (direct interaction, pull down) Altiok et al., J Biol Chem 1999*
• IRef Biogrid Interaction: AKT1 — BRCA1 (physical association, affinity chromatography technology) Xiang et al., Cancer Res 2008*
• IRef Biogrid Interaction: AKT1 — BRCA1 (direct interaction, pull down) Xiang et al., Cancer Res 2008*
• IRef Biogrid Interaction: AKT1 — BRCA1 (direct interaction, enzymatic study) Xiang et al., Cancer Res 2008*
• IRef Hprd Interaction: AKT1 — BRCA1 (in vivo) Altiok et al., J Biol Chem 1999*
• IRef Hprd Interaction: AKT1 — BRCA1 (in vitro) Altiok et al., J Biol Chem 1999*
• IRef Intact Interaction: AKT1 — BRCA1 (physical association, pull down) Xiang et al., Oncogene 2011*

Text-mined interactions from Literome

Altiok et al., J Biol Chem 1999 (Breast Neoplasms) : We showed that heregulin stimulation induced the phosphorylation of BRCA1 and concomitant activation of the serine/threonine kinase AKT in T47D human breast cancer cells
Hinton et al., Exp Cell Res 2007 (Breast Neoplasms) : Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1 ... This heregulin induced increase in nuclear BRCA1 is blocked by siRNA mediated down-regulation of Akt
Ma et al., Mol Endocrinol 2007 : These findings suggest that BRCA1 regulates Akt signaling and the PI3K/Akt pathway modulates the ability of BRCA1 to repress ER-alpha, in part through serine phosphorylation events in the activation function-1 domain of ER-alpha
Xiang et al., Cancer Res 2008 (Breast Neoplasms) : Negative Regulation of AKT Activation by BRCA1
Plo et al., Oncogene 2009 (Aneuploidy) : Concomitantly, AKT1 represses both BRCA1 foci formation and HR stimulation resulting from BRCA1 overexpression, showing that AKT1 affects BRCA1 mediated HR functions, also in another species ( hamster ) and in another type of cell tissue ( ovary cells )
Tonic et al., J Biol Chem 2010 : Akt prevents the translocation of BRCA1 to DNA damage foci and, thereby, inhibiting the activation of Chk1 following DNA damage
Jia et al., Oncogene 2013 (Breast Neoplasms...) : Our results indicate that Brca1 deficiency might activate Akt1 contributing to tumorigenesis through regulation of the Chk1-Rad51 signaling