Gene interactions and pathways from curated databases and text-mining

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BCR — STAT3

Text-mined interactions from Literome

Spiekermann et al., Exp Hematol 2002 (Cell Transformation, Neoplastic...) : Stable transfection of BA/F3 cells with TEL-JAK2, TEL-ABL, and BCR-ABL resulted in IL-3 independent growth and strong activation of STAT3 and STAT5 by TEL-JAK2 and TEL-ABL, but not by BCR-ABL
Coppo et al., Oncogene 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells
Nakamura et al., Oncogene 2005 (Cell Transformation, Neoplastic...) : These results indicate that MEKK1 plays a key role in Bcr-Abl induced STAT3 activation and in ES cells ' capacity for LIF independent self-renewal, and may thus be involved in Bcr-Abl mediated leukemogenesis in stem cells
Coppo et al., Br J Haematol 2006 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : BCR-ABL activates STAT3 via JAK and MEK pathways in human cells ... Using BCR-ABL mutants, it was shown that BCR-ABL tyrosine kinase activity and its Tyr177 residue were necessary for STAT3 Ser727 phosphorylation ... Inhibition of BCR-ABL with imatinib mesylate led to a dose dependent downregulation of total STAT3 protein and mRNA, suggesting that BCR-ABL is involved in the transcriptional regulation of STAT3
Otero et al., J Immunol 2006 : Importantly, STAT3 ( -/- ) B-1 cells become susceptible to irradiation, indicating that STAT3 activation by the BCR in the presence of IL costimuli account for the inherent radioresistance of peritoneal B-1 B cells
Wang et al., Oncogene 2007 : In an electrophoretic mobility shift assay, BCR stimulation led to enhanced DNA binding of the STAT3 in DT40, but not in the Lyn-null cells
Coppo et al., Cell Signal 2009 : To better understand the behavior of BCR-ABL in pluripotent stem cells, we previously developed a murine embryonic stem ( ES ) cell model transformed by p210-BCR-ABL and reported that BCR-ABL activates STAT3 , a major protein involved in ES cells self-renewal, which leads specifically to inhibition of ES cells differentiation