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AREG — IGF1

Text-mined interactions from Literome

Hurbin et al., J Biol Chem 2002 (Carcinoma, Non-Small-Cell Lung...) : In this report, we have identified a new mechanism of apoptosis inhibition by amphiregulin through an IGF1 dependent survival pathway in non-small cell lung cancer ( NSCLC ) cells : amphiregulin activates the IGF1 receptor that in turn induces the secretion of amphiregulin and IGF1 ... H358 conditioned medium and amphiregulin induce IGF1 receptor phosphorylation in H322 cells, which is prevented by anti-amphiregulin neutralizing antibody but not by AG556 or ZD1839 ... Finally, IGF1 receptor inhibitor blocks amphiregulin and IGF1 release by H358 cells
Rodland et al., J Biol Chem 2008 (MAP Kinase Signaling System) : Studies using anti-ligand antibodies showed that IGF-1 transactivation required amphiregulin production, whereas LPA was dependent on multiple ligands