◀ Back to AKT1
AKT1 — AKT2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Class I PI3K signaling events mediated by Akt:
AKT2 (AKT2)
→
AKT1 (AKT1)
(modification, collaborate)
Zhou et al., Nat Cell Biol 2001*, Héron-Milhavet et al., Mol Cell Biol 2006*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database E-cadherin signaling in keratinocytes:
AKT1-2-active (AKT1/AKT2)
→
AKT1-2 (AKT1/AKT2)
(modification, collaborate)
Calautti et al., J Biol Chem 2005*
Evidence: assay
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
AKT1-2-active (AKT1/AKT2)
→
AKT1-2 (AKT1/AKT2)
(modification, collaborate)
Zhang et al., J Neurosci Res 2000*, Xiao et al., Proc Natl Acad Sci U S A 2001*
Evidence: mutant phenotype, assay
-
WikiPathways DNA Damage Response (only ATM dependent):
PDK1
→
Complex of AKT1-AKT2-AKT3
(activation)
-
WikiPathways DNA Damage Response (only ATM dependent):
Complex of AKT1-AKT2-AKT3
→
FOXO3
(activation)
-
WikiPathways DNA Damage Response (only ATM dependent):
Complex of AKT1-AKT2-AKT3
→
CDKN1A
(activation)
-
WikiPathways DNA Damage Response (only ATM dependent):
ERBB2
→
Complex of AKT1-AKT2-AKT3
(activation)
-
WikiPathways DNA Damage Response (only ATM dependent):
PTEN
→
Complex of AKT1-AKT2-AKT3
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Hprd Interaction:
AKT1
—
AKT2
(in vivo)
Matsumoto et al., J Biol Chem 2001*, Chen et al., J Biol Chem 2001*, Hellyer et al., J Biol Chem 2001*, Conus et al., J Biol Chem 2002*, Hill et al., Curr Biol 2002*, Shenoy et al., J Immunol 2003*, Delcommenne et al., Proc Natl Acad Sci U S A 1998
-
IRef Hprd Interaction:
AKT1
—
AKT2
(in vitro)
Matsumoto et al., J Biol Chem 2001*, Chen et al., J Biol Chem 2001*, Hellyer et al., J Biol Chem 2001*, Conus et al., J Biol Chem 2002*, Hill et al., Curr Biol 2002*, Shenoy et al., J Immunol 2003*, Delcommenne et al., Proc Natl Acad Sci U S A 1998
Text-mined interactions from Literome
Tiganis et al., J Biol Chem 1999
:
We find that the integrin mediated activation of
PKB/Akt in COS1 cells is abrogated by the specific EGF receptor protein-tyrosine kinase inhibitor tyrphostin AG1478, and that TC45 and TC45-D182A can
inhibit activation of
PKB/Akt following the attachment of COS1 cells to fibronectin
Brognard et al., Cancer Res 2001
(Carcinoma, Non-Small-Cell Lung...) :
Akt/PKB activation was phosphatidylinositol 3-kinase dependent and promoted survival because the phosphatidylinositol 3 inhibitors LY294002 and wortmannin
inhibited Akt/PKB phosphorylation,
Akt/PKB activity, and increased apoptosis only in cells with active Akt/PKB
Fukuda et al., J Cell Biol 2003
:
Thus, CH-ILKBP is an important component of the prosurvival signaling pathway functioning primarily by facilitating the membrane translocation of
PKB/Akt and consequently the
activation of
PKB/Akt in response to extracellular survival signals
Peng et al., Genes Dev 2003
(Abnormalities, Multiple...) :
Specifically,
Akt1 and Akt2 are
required for the induced expression of PPARgamma, the master regulator of adipogenesis, establishing a new essential role for
Akt in adipocyte differentiation ... Specifically, Akt1 and
Akt2 are
required for the induced expression of PPARgamma, the master regulator of adipogenesis, establishing a new essential role for
Akt in adipocyte differentiation
Nomura et al., Mol Carcinog 2003
(Cell Transformation, Neoplastic) :
The expression of
DNM-Akt1 also
suppressed EGF induced p70 S6K activation as well as
Akt activation
Fukazawa et al., J Mol Cell Cardiol 2003
:
NRG-1beta treatment induced rapid activation of
Akt/PKB that was inhibited by wortmannin, and adenoviral mediated overexpression of a dominant negative
Akt prevented the protective effect of NRG-1beta
Lee et al., Int J Oncol 2004
(Stomach Neoplasms) :
In contrast,
PKB/Akt regulation by TGF-beta1 was not different in suspension or in adhesion, and Smad7, but not the other Smads,
activated PKB/Akt phosphorylation on TGF-beta1 treatment, indicating a specificity of Smad2 mediated and cell adhesion status dependent activation of Erk1/2 activity
Dickson et al., Am J Physiol Endocrinol Metab 2004
(Diabetes Mellitus, Type 2...) :
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes : a
role for
protein kinase B in the
Akt ?
Sedding et al., Circ Res 2005
:
Previously, we demonstrated a mechanosensitive
activation of phosphoinositide 3-kinase
(PI3-K)/protein kinase B (
Akt ) resulting in p27Kip1 transcriptional downregulation and cell cycle entry of vascular smooth muscle cells ( VSMC )
Wang et al., Cell Res 2005
:
We found that arsenic trioxide induced the expression and the phosphorylation of
Akt/PKB and it
inhibited the interaction between
Akt/PKB and PPARgamma
Culig et al., Endocr Relat Cancer 2005
(Neoplasms, Hormone-Dependent...) :
Similarly,
activation of the AR by phosphorylated
protein kinase B ,
Akt , has also been reported in prostate cancer
Fisher et al., Am J Physiol Endocrinol Metab 2005
:
We hypothesized that AMP activated protein kinase related kinase 5 ( ARK5 ) /novel kinase family 1 ( NUAK1 ), an AMP activated protein kinase (AMPK) related kinase that has been found to be
stimulated by
protein kinase B (
Akt ), would be expressed in rat skeletal muscle and activated by electrically elicited contractions, 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside ( AICAR ), or insulin
Dang et al., J Neurosci Res 2005
(Neurofibromatoses) :
Although the c-Kit ligand stem cell factor (SCF)
induces the phosphorylation of
protein kinase B ( or
Akt ) and prevents apoptosis in Schwann cells, SCF has no effect on the proliferation or differentiation of Schwann cells
Stojanovic et al., J Biol Chem 2006
:
Agonist induced elevation of NO and cGMP was inhibited by
Akt inhibitors and
reduced in
Akt-1 knock-out platelets
Stoeltzing et al., Cancer Cell 2006
(Neoplasms...) :
In this issue of Cancer Cell, Phung and coworkers demonstrate that sustained endothelial
activation of
Akt by expression of constitutively activated
Akt1 ( myrAkt1 ) leads to blood vessels that essentially recapitulate the complex structural and functional abnormalities of tumor vessels
Osman et al., Cancer 2006
(Disease Progression...) :
Loss of neutral endopeptidase and
activation of
protein kinase B (
Akt ) is associated with prostate cancer progression
Sun et al., Neuroscience 2007
(Pain) :
The
PKB/Akt inhibitor,
Akt inhibitor IV, has the same effect
Creighton et al., Oncogene 2007
(Breast Neoplasms...) :
The subset of genes both upregulated by Akt and dependent on mTOR activity were associated with estrogen receptor negative status, higher grade, increasing tumor size and poor prognosis in multiple patient cohorts ; these associations were either not present or not as strong for the
Akt induced , mTOR independent genes or for
AKT1 expression alone
Lengyel et al., Steroids 2007
:
In response to E2, phosphorylation of
Akt/PKB on Ser473 and FOXO1 on Ser256 and Thr24 residues increased but with distinct kinetics,
regulating the activation and inactivation of
Akt and FOXO1 proteins, respectively
Kang et al., J Exp Med 2007
(Pulmonary Fibrosis) :
TGF-beta(1) and bleomycin also activated phosphatidylinositol 3-kinase (PI3K) and protein kinase B
(PKB)/AKT via SEMA 7A-dependent mechanisms, and
PKB/AKT inhibition
diminished TGF-beta(1) induced fibrosis
Segrelles et al., Mol Biol Cell 2008
(Nails, Malformed...) :
Here we report the developmental consequences of deregulated
Akt activity in the basal layer of stratified epithelia,
mediated by the expression of a constitutively active
Akt1 ( myrAkt ) in transgenic mice
Mutiara et al., Mol Cell Endocrinol 2008
:
Akt/PKB activation by GnRH and IGF-1 was completely eliminated in the presence of the PI3-kinase inhibitor, LY 294002, but not in the
presence of an
Akt/PKB inhibitor
Oehler-Jänne et al., Biochem Biophys Res Commun 2008
:
Down-regulation of p-Ser ( 473 )
-PKB/Akt was reversible and re-exposure to physiological temperature
resulted in increased p-Ser ( 473 )
-PKB/Akt phosphorylation levels
Ritchie et al., Biochem J 2010
:
Insulin stimulates endothelial NO ( nitric oxide ) synthesis via
PKB ( protein kinase B )
/Akt mediated phosphorylation and activation of eNOS ( endothelial NO synthase ) at Ser-1177
Subramanyam et al., J Biol Chem 2010
:
Thus, it is concluded that in human epithelial cells, shrinkage induced activation of
Akt1 is involved in the RVI process and that apoptotic inhibition of RVI is
caused by inhibition of
Akt activation, which results from ROS mediated activation of ASK1
Huang et al., Cardiovasc Drugs Ther 2011
(Disease Models, Animal...) :
LV-IS-reduction induced by esmolol + milrinone was eliminated in the presence of protein kinase A-(PKA)-inhibitor ( Rp-cAMPS ) or
Akt-inhibitor (
AKT 1/2 kinase
inhibitor ) ... LV-IS-reduction induced by esmolol + milrinone was eliminated in the presence of protein kinase A-(PKA)-inhibitor ( Rp-cAMPS ) or
Akt-inhibitor (
AKT 1/2 kinase
inhibitor )
Moore et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
mTORC2 protein complex
mediated Akt ( Protein Kinase B ) Serine 473 Phosphorylation is not required for
Akt1 activity in human platelets [ corrected ]
Norrby et al., Journal of molecular signaling 2012
:
In denervated hypertrophic muscle expression of total
Akt1 ,
Akt2 , GSK-3beta, p70S6K1 and rpS6 proteins
increased 2-10 fold whereas total 4EBP1 protein remained unaltered
Dai et al., PloS one 2012
(Acute Disease...) :
Here, we demonstrate for the first time that acute ECM results in significantly reduced activation of
protein kinase B ( PKB or Akt )
leading to decreased
Akt phosphorylation and inhibition of the glycogen kinase synthase ( GSK3ß ) in the brains of mice infected with Plasmodium berghei ANKA ( PbA ) compared to uninfected controls and to mice infected with the non-neurotrophic P. berghei NK65 ( PbN )
Walker et al., Biochem J 1998
:
Insulin
induced the activation of
PKBalpha in rat skeletal muscle in vivo, with little activation of
PKBbeta