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AGTR1 — STAT3

Text-mined interactions from Literome

Horiuchi et al., Circ Res 1999 : In the present study, we report that the stimulation of AT2 receptor in AT2 receptor cDNA transfected rat adult vascular smooth muscle cells ( VSMCs ) inhibited angiotensin II type 1 (AT1) receptor mediated tyrosine phosphorylation of STAT ( signal transducers and activators of transcription ) 1alpha/beta, STAT2, and STAT3 without influence on Janus kinase
Omura et al., J Mol Cell Cardiol 2000 (Myocardial Infarction) : Thus, the transcriptional activation of STAT3 through AT1 receptor may be partially involved in cardiac remodeling after myocardial infarction
Yue et al., Cardiovasc Res 2010 (Cardiomegaly) : Chronic activation of AT1R induces unregulated expression of the Stat3 gene, leading to nuclear accumulation of U-STAT3, which significantly correlated with progression of cardiac hypertrophy
Kandalam et al., Regul Pept 2010 : Our study showed for the first time that Ang II induced JAK2/STAT3 phosphorylation and IL-6 secretion through activation of the Ang II AT(1) receptor in brainstem astrocytes