Gene interactions and pathways from curated databases and text-mining

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ADORA2B — MAPK3

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: MAPK3 → ADORA2B (increases, ADORA2B Activity, MAPK3 Activity) Wyatt et al., FASEB J 2002*
    Evidence: Expression of mRNA for the A2a-, A2b-adenosine receptor subtypes was abundant whereas A1-adenosine receptor mRNA levels were negligible. Activation of A2a purinoceptors by adenosine (10 microM) or the A2a receptor agonist CGS21680 (100 nM) resulted in an increase in l-arginine transport and NO release that was not mediated by changes in intracellular Ca2+, pH, or cAMP.