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PDGFA — VEGFA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: VEGFA → Complex of PDGFA-PDGFB (increases) Heldin et al., Physiol Rev 1999
  Evidence: However, in specific organs, the effect of PDGF on angiogenesis may be significant. Thus stimulation of PDGF-AB production in cardiac microvascular cells leads to induction of both von Willebrand factor and VEGF and VEGF receptor-2, suggesting an important role of PDGF in cardiac angiogenesis (110).
• OpenBEL Selventa BEL large corpus: VEGFA → Complex of PDGFA-PDGFB (increases) Nauck et al., Am J Respir Cell Mol Biol 1997*
  Evidence: The transcriptional activation was accompanied by increased levels of VEGF protein
• OpenBEL Selventa BEL large corpus: VEGFA → PDGFA (increases) Nauck et al., Am J Respir Cell Mol Biol 1997*
  Evidence: The transcriptional activation was accompanied by increased levels of VEGF protein

Text-mined interactions from Literome

Oak et al., Arterioscler Thromb Vasc Biol 2003 (MAP Kinase Signaling System) : The PDGFAB induced expression of VEGF was markedly reduced by SB203580 ( inhibitor of p38 mitogen activated protein kinase [ MAPK ] ), antioxidants, and diphenylene iodonium ( inhibitor of flavin dependent enzymes ), slightly reduced by PD98059 ( inhibitor of MEK ), and not significantly affected by wortmannin ( inhibitor of PI-3-kinase ) and L-JNKI ( inhibitor of JNK )
Xaymardan et al., J Exp Med 2004 (Coronary Disease...) : In vitro PDGF-AB induced vascular endothelial growth factor ( VEGF ) and angiopoietin (Ang)-2 expression in 4-mo-old rat cardiac endothelial cells, but not in 24-mo-old heart cells
Shikada et al., Cancer Res 2005 (Carcinoma, Non-Small-Cell Lung...) : To directly assess the expression of PDGF-AA dependent VEGF and its roles in tumorigenesis, we stably transfected established cell lines with their antisense genes ... PDGF-AA tightly regulated VEGF expression and had a greater effect on tumor size and patient prognosis than did VEGF in both cell lines and surgical sections
Oak et al., Br J Pharmacol 2006 (MAP Kinase Signaling System) : Delphinidin and cyanidin inhibit PDGF(AB) induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK ... The inhibitory effect of RWPs on PDGF(AB) induced release of VEGF was mimicked by delphinidin but not by quercetin, catechins, resveratrol, gallic acid or caffeic acid ... Although the p38 MAPK, ERK1/2 and JNK pathways have been involved in the PDGF(AB) induced expression of VEGF , in our experiments, only phosphorylation of p38 MAPK and JNK was inhibited by RWPs, delphinidin and cyanidin ... Anthocyanins presenting a hydroxyl residue at position 3 ' are able to inhibit PDGF(AB) induced VEGF expression by preventing activation of p38 MAPK and JNK in VSMCs
Kowarik et al., Exp Clin Endocrinol Diabetes 2010 : To further characterize the role of PDGF in TtT/GF cells, the effect of PDGF-AB and -BB on growth and vascular endothelial growth factor-A ( VEGF-A ) release was studied ... Both in rat pituitary cell cultures and in TtT/GF cells, PDGF-AB and -BB strongly enhanced VEGF-A secretion