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NOS1 — VEGFA

Text-mined interactions from Literome

Feng et al., Biochem Biophys Res Commun 1999 : VEGF induces nuclear translocation of Flk-1/KDR, endothelial nitric oxide synthase , and caveolin-1 in vascular endothelial cells
Jozkowicz et al., Cardiovasc Res 2001 : Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF
Lal et al., Microvasc Res 2001 (MAP Kinase Signaling System) : We tested the hypothesis that VEGF regulates endothelial cell ( EC ) permeability by activating PKB/akt, NOS , and MAP kinase dependent pathways using human umbilical vein EC ( HUVEC )
Joussen et al., Am J Pathol 2002 (Diabetes Mellitus, Experimental...) : Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo
Ando et al., J Cell Physiol 2002 (Ischemia...) : In mice with oxygen induced ischemic retinopathy, deficiency of eNOS, but not iNOS or nNOS caused a significant decrease in retinal neovascularization and decreased expression of VEGF
Park et al., J Korean Med Sci 2002 (MAP Kinase Signaling System) : Expression and regulation of endothelial nitric oxide synthase by vascular endothelial growth factor in ECV 304 cells
Tazi et al., Gastroenterology 2002 (Constriction, Pathologic...) : VEGF induced stimulation of NOS activity was greater in aortas from control rats than in aortas from portal vein stenosed or cirrhotic rat aortas
Jin et al., Circ Res 2003 : Ligand independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase
Wang et al., Bone 2004 : Inhibition of NOS activity by N-nitro-L-arginine methyl ester ( L-NAME ) or blockade of guanylate cyclase activity by ODQ reduced US-augmented HIF-1alpha transactivation and VEGF-A levels
Bauer et al., Proc Natl Acad Sci U S A 2005 : Second, despite a lack of quantitative changes in organelle number, endothelial-specific expression of Cav-1 impairs endothelial nitric oxide synthase activation, endothelial barrier function, and angiogenic responses to exogenous VEGF and tissue ischemia
Yu et al., Proc Natl Acad Sci U S A 2005 (Ischemia...) : The genetic loss of endothelial derived nitric oxide synthase ( eNOS ) in mice impairs vascular endothelial growth factor ( VEGF ) and ischemia initiated blood flow recovery resulting in critical limb ischemia
Feliers et al., Kidney Int 2005 (MAP Kinase Signaling System) : VEGF regulation of endothelial nitric oxide synthase in glomerular endothelial cells
Ahmed et al., Fetal Pediatr Pathol 2005 (Hydatidiform Mole) : Endothelial nitric oxide synthase is induced by vascular endothelial growth factor and has been implicated in the pathogenesis of preeclampsia and other physiologic conditions in the placenta
Xie et al., J Sex Med 2005 (Erectile Dysfunction...) : VEGF signaling leads to the phosphorylation of Akt and endothelial nitric oxide synthase ( p-Akt and p-eNOS )
Bardal et al., Diabetologia 2006 (Diabetes Mellitus, Experimental) : VEGF also prevented the apparent paradoxical increased endothelial nitric oxide synthase expression seen in untreated STZ rats
Camp et al., Clin Cancer Res 2006 (Neovascularization, Pathologic...) : Roles of nitric oxide synthase inhibition and vascular endothelial growth factor receptor-2 inhibition on vascular morphology and function in an in vivo model of pancreatic cancer
Sirinyan et al., Stroke 2006 (Atrophy) : NOS inhibitors and eNOS deletion as well as an SOD mimetic ( CuDIPS ) restore vascular endothelial growth factor receptor-2 levels and nearly abolish the vasoobliteration
Savas et al., Spinal Cord 2008 (Spinal Cord Injuries) : However, nonselective inhibition of NOS with L-NAME significantly decreased MDA and NO, but increased VEGF levels
González et al., Lab Invest 2007 (Birth Weight...) : Amniotic fluid from preeclamptic women, but not from normal women, inhibited vascular endothelial growth factor induced endothelial cell proliferation and nitric oxide synthase activity in cultured endothelial cells, and these actions were reversed by antibodies able to neutralize the effects of vasoinhibins
He et al., Pathobiology 2007 (Anoxia...) : Inducible nitric oxide synthase mediates hypoxia induced hypoxia-inducible factor-1 alpha activation and vascular endothelial growth factor expression in oxygen induced retinopathy
García et al., J Clin Invest 2008 (Diabetic Retinopathy...) : Inhibition by vasoinhibins was similar to that achieved following immunodepletion of VEGF from human diabetic retinopathy vitreous or blockage of NO synthesis, suggesting that vasoinhibins inhibit VEGF induced NOS activation
Heo et al., Immunol Lett 2008 (Inflammation) : Moreover, NOS inhibitor ( L-NAME ) and anti-TLR 4mAb reduced the LPS induced NO, IL-8 and VEGF production and ICAM-1 expression
Ferraro et al., Mol Ther 2009 : The short-term increase in VEGF was sufficient to mediate an upregulation of endothelial nitric oxide synthase , an angiogenic factor that increases vascular permeability
Olszewska-Pazdrak et al., Am J Physiol Cell Physiol 2009 (Anoxia...) : Hypoxia attenuated VEGF stimulated activation of endothelial nitric oxide ( NO ) synthase ( eNOS ) ( approximately 72 % ) and reduced NO production in VEGF stimulated cells from 237 +/- 38.8 to 61.3 +/- 28.4 nmol/l
Trouillon et al., Biochim Biophys Acta 2010 : Our results show that carefully applied layers of fibronectin have a very limited effect on electrochemistry and that VEGF induces an increase in NOS activity that is mainly mediated through the phosphatidylinositol 3 kinase (PI-3), and not by the extracellular signal regulated kinases 1/2
Wheat et al., Arterioscler Thromb Vasc Biol 2011 : Exposure to acrolein blocked vascular endothelial growth factor ( VEGF ) /AMD3100 stimulated mobilization of Flk-1 ( + ) /Sca-1 ( + ) but not Sca-1 ( + ) -only cells and prevented VEGF induced phosphorylation of Akt and endothelial nitric oxide synthase in the aorta
Hou et al., Cardiovasc Res 2012 : N-terminal domain of soluble epoxide hydrolase negatively regulates the VEGF mediated activation of endothelial nitric oxide synthase
Lankhorst et al., J Hypertens 2013 (Hypertension...) : As VEGF increases the expression and the activity of nitric oxide synthase in endothelial cells, a decrease in the bioavailability of nitric oxide has been proposed as a key mechanism leading to hypertension during angiogenesis inhibition
Yoshida et al., Circulation 2013 (Feminization...) : In in vitro studies, siRNA mediated ablation of AR in vascular endothelial cells blunted VEGF stimulated phosphorylation of Akt and endothelial nitric oxide synthase
Bryant et al., Life Sci 1998 : The effect of the angiogenic cytokine vascular endothelial growth factor ( VEGF ) on nitric oxide synthase (NOS) and cyclooxygenase (COX) expression was examined in human ( HUVEC ) and bovine ( BAE ) endothelial cells