Gene interactions and pathways from curated databases and text-mining

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IL10 — VEGFA

Text-mined interactions from Literome

Gloddek et al., J Endocrinol 1999 : Pituitary adenylate cyclase activating polypeptide, interleukin-6 and glucocorticoids regulate the release of vascular endothelial growth factor in pituitary folliculostellate cells
Matsumoto et al., Am J Nephrol 1999 (Glomerulonephritis, IGA...) : To gain insight into the immunoregulatory properties of these cytokines, we analyzed the effects of recombinant human IL-4 and IL-10 on VPF release in MCNS patients
Tsuji et al., Biol Pharm Bull 2000 : Effects of sulfhydryl compounds on interleukin-1 induced vascular endothelial growth factor production in human synovial stromal cells
Mor et al., J Immunol 2004 (Anoxia...) : Indeed, VEGF augmented IFN-gamma and inhibited IL-10 secretion by T cells responding to mitogen or Ag ; thus, VEGF can enhance a Th1 phenotype
Inoue et al., Rheumatol Int 2005 (Osteoarthritis, Hip...) : Induction of vascular endothelial growth factor and matrix metalloproteinase-3 ( stromelysin ) by interleukin-1 in human articular chondrocytes and synoviocytes
Schmeding et al., Transplantation 2010 (Fatty Liver) : Analysis of liver enzymes, histology ( hematoxylin-eosin and periodic acid Schiff stain ), immunostaining ( terminal deoxynucleotide transferase- mediated dUTP nick-end labeling, hypoxyprobe, and tumor necrosis factor-alpha ), and reverse transcriptase-polymerase chain reaction of cytokine messenger RNA ( interleukin-1 , interleukin-6, hypoxia induced factor-1 alpha, vascular endothelial growth factor , and hepatocyte growth factor ) were performed at defined time points ( 2, 4.5, 24, 48 hr, and 7 days postoperatively )
Wu et al., Immunobiology 2010 (Anoxia...) : IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia ... In this study, we have demonstrated that IL-10 inhibits M1 bone marrow derived macrophages ( BMDMs ) VEGF , stimulated by LPS/CGS21680 ( adenosine A2A receptor agonist ), but does not prevent VEGF production from M2 macrophages stimulated with prostaglandin E2 ( PGE2 ) ... Our results indicate IL-10 suppressed M1 but not M2 derived VEGF , and that activation signals determined the influence of IL-10 on VEGF production
Chew et al., BMC cancer 2010 (Nasopharyngeal Neoplasms...) : The present study examined the roles of EBV latent membrane protein-1 (LMP1), interleukin-6 (IL-6), interleukin-10 (IL-10) , transforming growth factor-beta 1 ( TGF-ß1 ) and laminin in the regulation of matrix-metalloproteinases ( MMPs ) and vascular endothelial growth factor ( VEGF ) in NPC ... The present study examined the roles of EBV latent membrane protein-1 (LMP1), interleukin-6 (IL-6), interleukin-10 (IL-10), transforming growth factor-beta 1 ( TGF-ß1 ) and laminin in the regulation of matrix-metalloproteinases ( MMPs ) and vascular endothelial growth factor ( VEGF ) in NPC
Demyanets et al., Basic Res Cardiol 2011 (Atherosclerosis...) : Interferon-? ( IFN-? ), but not IL-4 or IL-10 , reduced OSM induced VEGF production in vascular SMC
Grimstad et al., Wound Repair Regen 2011 : New interactions between cytokines and growth factors were revealed, which may have important roles in wound healing, including IL-1ß induced IFN-? and IL-10 induced VEGF
Choe et al., Joint Bone Spine 2012 (Arthritis, Rheumatoid...) : Tacrolimus ( FK506 ) inhibits interleukin-1ß induced angiopoietin-1, Tie-2 receptor, and vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes
Krishnamurthy et al., Circ Res 2011 (Myocardial Infarction...) : In vitro, IL-10 induced increase in VEGF expression in WT EPC was abrogated by STAT3 inhibitor, suggesting IL-10 signals through STAT3 activation
Linde et al., J Pathol 2012 (Disease Models, Animal...) : However, VEGF-A alone is not sufficient to create a tumour promoting microenvironment and requires the presence of IL-4 and IL-10 to induce M2 polarization of macrophages
Oderup et al., J Immunol 2013 : Wnt3A triggers canonical ß-catenin signaling and preferentially induces DC TGF-ß and VEGF production, whereas Wnt5A induces IL-10 through alternative pathways
Ben-Av et al., FEBS Lett 1995 (Arthritis, Rheumatoid...) : Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1 : a potential mechanism for inflammatory angiogenesis
Matsumoto et al., Clin Exp Immunol 1995 (Nephrosis, Lipoid) : These imply that there is a relative deficit in IL-10 release in active LN, which suggests the possibility that inadequate release of IL-10 may lead to increased VPF activity in active LN patients and the measurements of IL-10 may be of value for monitoring kidney disease
Kvanta et al., Curr Eye Res 1995 : Both interleukin-1 and transforming growth factor beta induced VEGF expression in choroidal fibroblasts although with different time courses ... By using Western blotting, it was further found that stimulation with interleukin-1 induced VEGF protein expression in choroidal fibroblasts but not in RPE cells
Matsumoto et al., Nephron 1997 (Glomerulonephritis, IGA...) : Interleukin 10 inhibits vascular permeability factor release by peripheral blood mononuclear cells in patients with lipoid nephrosis ... The effect of recombinant human interleukin 10 (IL-10) on the in vitro secretion of vascular permeability factor (VPF) of peripheral blood mononuclear cells ( PBMC ) was evaluated in patients with lipoid nephrosis ( LN ) ... In the present study, IL-10 inhibited the ConA stimulated VPF secretion of PBMC in LN
Matsumoto et al., Nephron 1997 (Glomerulonephritis, IGA...) : Interleukin 10 and interleukin 13 synergize to inhibit vascular permeability factor release by peripheral blood mononuclear cells from patients with lipoid nephrosis ... These results prompted us to study the effects of recombinant human IL-10 and IL-13 on VPF secretion in LN