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IL10 — VEGFA
Text-mined interactions from Literome
Gloddek et al., J Endocrinol 1999
:
Pituitary adenylate cyclase activating polypeptide,
interleukin-6 and glucocorticoids
regulate the release of
vascular endothelial growth factor in pituitary folliculostellate cells
Matsumoto et al., Am J Nephrol 1999
(Glomerulonephritis, IGA...) :
To gain insight into the immunoregulatory properties of these cytokines, we analyzed the
effects of recombinant human IL-4 and
IL-10 on
VPF release in MCNS patients
Tsuji et al., Biol Pharm Bull 2000
:
Effects of sulfhydryl compounds on
interleukin-1 induced
vascular endothelial growth factor production in human synovial stromal cells
Mor et al., J Immunol 2004
(Anoxia...) :
Indeed,
VEGF augmented IFN-gamma and
inhibited IL-10 secretion by T cells responding to mitogen or Ag ; thus, VEGF can enhance a Th1 phenotype
Inoue et al., Rheumatol Int 2005
(Osteoarthritis, Hip...) :
Induction of
vascular endothelial growth factor and matrix metalloproteinase-3 ( stromelysin ) by
interleukin-1 in human articular chondrocytes and synoviocytes
Schmeding et al., Transplantation 2010
(Fatty Liver) :
Analysis of liver enzymes, histology ( hematoxylin-eosin and periodic acid Schiff stain ), immunostaining ( terminal deoxynucleotide transferase- mediated dUTP nick-end labeling, hypoxyprobe, and tumor necrosis factor-alpha ), and reverse transcriptase-polymerase chain reaction of cytokine messenger RNA (
interleukin-1 , interleukin-6, hypoxia
induced factor-1 alpha,
vascular endothelial growth factor , and hepatocyte growth factor ) were performed at defined time points ( 2, 4.5, 24, 48 hr, and 7 days postoperatively )
Wu et al., Immunobiology 2010
(Anoxia...) :
IL-10 regulation of macrophage
VEGF production is dependent on macrophage polarisation and hypoxia ... In this study, we have demonstrated that
IL-10 inhibits M1 bone marrow derived macrophages ( BMDMs )
VEGF , stimulated by LPS/CGS21680 ( adenosine A2A receptor agonist ), but does not prevent VEGF production from M2 macrophages stimulated with prostaglandin E2 ( PGE2 ) ... Our results indicate
IL-10 suppressed M1 but not M2 derived
VEGF , and that activation signals determined the influence of IL-10 on VEGF production
Chew et al., BMC cancer 2010
(Nasopharyngeal Neoplasms...) :
The present study examined the
roles of EBV latent membrane protein-1 (LMP1), interleukin-6 (IL-6),
interleukin-10 (IL-10) , transforming growth factor-beta 1 ( TGF-ß1 ) and laminin in the regulation of matrix-metalloproteinases ( MMPs ) and
vascular endothelial growth factor ( VEGF ) in NPC ... The present study examined the
roles of EBV latent membrane protein-1 (LMP1),
interleukin-6 (IL-6), interleukin-10 (IL-10), transforming growth factor-beta 1 ( TGF-ß1 ) and laminin in the regulation of matrix-metalloproteinases ( MMPs ) and
vascular endothelial growth factor ( VEGF ) in NPC
Demyanets et al., Basic Res Cardiol 2011
(Atherosclerosis...) :
Interferon-? ( IFN-? ), but not IL-4 or
IL-10 ,
reduced OSM induced
VEGF production in vascular SMC
Grimstad et al., Wound Repair Regen 2011
:
New interactions between cytokines and growth factors were revealed, which may have important roles in wound healing, including IL-1ß induced IFN-? and
IL-10 induced
VEGF
Choe et al., Joint Bone Spine 2012
(Arthritis, Rheumatoid...) :
Tacrolimus ( FK506 ) inhibits
interleukin-1ß induced angiopoietin-1, Tie-2 receptor, and
vascular endothelial growth factor through down-regulation of JNK and p38 pathway in human rheumatoid fibroblast-like synoviocytes
Krishnamurthy et al., Circ Res 2011
(Myocardial Infarction...) :
In vitro,
IL-10 induced increase in
VEGF expression in WT EPC was abrogated by STAT3 inhibitor, suggesting IL-10 signals through STAT3 activation
Linde et al., J Pathol 2012
(Disease Models, Animal...) :
However,
VEGF-A alone is not sufficient to create a tumour promoting microenvironment and
requires the presence of IL-4 and
IL-10 to induce M2 polarization of macrophages
Oderup et al., J Immunol 2013
:
Wnt3A triggers canonical ß-catenin signaling and preferentially
induces DC TGF-ß and
VEGF production, whereas Wnt5A induces
IL-10 through alternative pathways
Ben-Av et al., FEBS Lett 1995
(Arthritis, Rheumatoid...) :
Induction of
vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and
interleukin-1 : a potential mechanism for inflammatory angiogenesis
Matsumoto et al., Clin Exp Immunol 1995
(Nephrosis, Lipoid) :
These imply that there is a relative deficit in IL-10 release in active LN, which suggests the possibility that inadequate release of
IL-10 may
lead to increased
VPF activity in active LN patients and the measurements of IL-10 may be of value for monitoring kidney disease
Kvanta et al., Curr Eye Res 1995
:
Both
interleukin-1 and transforming growth factor beta
induced VEGF expression in choroidal fibroblasts although with different time courses ... By using Western blotting, it was further found that stimulation with
interleukin-1 induced
VEGF protein expression in choroidal fibroblasts but not in RPE cells
Matsumoto et al., Nephron 1997
(Glomerulonephritis, IGA...) :
Interleukin 10 inhibits
vascular permeability factor release by peripheral blood mononuclear cells in patients with lipoid nephrosis ... The
effect of recombinant human
interleukin 10 (IL-10) on the in vitro secretion of
vascular permeability factor (VPF) of peripheral blood mononuclear cells ( PBMC ) was evaluated in patients with lipoid nephrosis ( LN ) ... In the present study,
IL-10 inhibited the ConA stimulated
VPF secretion of PBMC in LN
Matsumoto et al., Nephron 1997
(Glomerulonephritis, IGA...) :
Interleukin 10 and interleukin 13 synergize to
inhibit vascular permeability factor release by peripheral blood mononuclear cells from patients with lipoid nephrosis ... These results prompted us to study the
effects of recombinant human
IL-10 and IL-13 on
VPF secretion in LN