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KLK5 — TSLP

Text-mined interactions from Literome

Briot et al., J Exp Med 2009 (Dermatitis, Atopic...) : Kallikrein 5 induces atopic dermatitis-like lesions through PAR2 mediated thymic stromal lymphopoietin expression in Netherton syndrome ... This is part of an original biological cascade in which unregulated kallikrein (KLK) 5 directly activates proteinase activated receptor 2 and induces nuclear factor kappaB mediated overexpression of TSLP , intercellular adhesion molecule 1, tumor necrosis factor alpha, and IL8
Briot et al., J Invest Dermatol 2010 (Dermatitis...) : This signaling is initiated by unrestricted kallikrein 5 (KLK5) activity, which directly activates proteinase activated receptor 2 (PAR2) mediated expression of TSLP and favors a cutaneous proallergic microenvironment independently of the environment and of the adaptive immune system