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MAP3K7 — TRAF2

Pathways - manually collected, often from reviews:

• KEGG Osteoclast differentiation: TRAF2/TRAF6 → Complex of MAP3K7-TAB1-TAB2 (protein-protein, activation)
  
• KEGG RIG-I-like receptor signaling pathway: TRAF2 → MAP3K7 (protein-protein, activation)
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF) (modification, collaborate)
  Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-TNF) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, collaborate)
  Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF) → TAK1/TAB family complex (MAP3K7-TAB2_TAB1) (modification, collaborate)
  Blonska et al., J Biol Chem 2005, Li et al., J Biol Chem 2006, Ea et al., Mol Cell 2006
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF) → sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF) (modification, collaborate)
  Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF) → MEKK3 (MAP3K3) (modification, collaborate) Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K7-TAB2_TAB1-TNF) → MEKK3 (MAP3K3) (modification, collaborate) Yang et al., Nat Immunol 2001, Blonska et al., J Biol Chem 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database TNF receptor signaling pathway : sTNF-alpha/TNFR1A/TRADD/RIP/TRAF2/TAK1/TAB family/MEKK3 complex (TNFRSF1A-TRADD-RIPK1-TRAF2-MAP3K3-MAP3K7-TAB2_TAB1-TNF) → IKK complex complex (CHUK-IKBKB-IKBKG) (modification, activates)
  Devin et al., Immunity 2000, Yang et al., Nat Immunol 2001, Ducut Sigala et al., Science 2004, Blonska et al., J Biol Chem 2005
  Evidence: mutant phenotype, assay, physical interaction
• WikiPathways RIG-I-like Receptor Signaling: TRAF2 → MAP3K7 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TRAF2 — MAP3K7 (physical association, affinity chromatography technology) Hong et al., Nat Immunol 2007
• IRef Biogrid Interaction: TRAF2 — MAP3K7 (physical association, affinity chromatography technology) Ishitani et al., EMBO J 2003
• IRef Hprd Interaction: Complex of 82 proteins (in vivo) Matsuzawa et al., Science 2008
• IRef Innatedb Interaction: TRAF2 — MAP3K7 (unknown, -) Hong et al., Nat Immunol 2007
• IRef Innatedb Interaction: TRAF2 — MAP3K7 (unknown, -) Ishitani et al., EMBO J 2003
• IRef Intact Interaction: TRAF2 — MAP3K7 (physical association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Ophid Interaction: TRAF2 — MAP3K7 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Lee et al., J Biochem Mol Biol 2002 : The AP1 activation by TRAF2, TRAF5 , and TRAF6 was also greatly suppressed by the dominant negative TAK1
Pantano et al., Am J Respir Cell Mol Biol 2007 : Furthermore, Nox1 used the TNF-RI adaptor protein TNF-receptor associated factor-2 (TRAF2) , and the redox regulated JNK MAP3K , apoptosis signal kinase-1 (ASK1), to activate JNK