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TIMP3 — TP53
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Thomas et al., Cancer Lett 2006
(Cell Transformation, Neoplastic) :
The ability of tumor derived
p53 mutants to
inhibit TIMP-3 expression provides a novel mechanism for understanding how p53 mutations might contribute to tumorigenesis ... We present the results of experiments that begin to determine the mechanism by which mutant
p53 represses
TIMP-3 gene expression
Finan et al., Lung Cancer 2006
(Genetic Predisposition to Disease) :
Overexpression of
TIMP-3 resulted in apoptosis of A549 lung cancer cells and AdCMVTIMP3
up-regulated the expression of
p53 , Fas ligand, TNFR1 and TNFR2 on these cells
Zhang et al., Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2007
(Neoplasm Invasiveness...) :
Overexpression of
TIMP-3 markedly
increased p53 protein level in spite of the backgrounds of p53 gene in cells
Zhang et al., Zhonghua Zhong Liu Za Zhi 2007
(Carcinoma, Squamous Cell...) :
Exogenous overexpression of
TIMP-3 increased
p53 protein level markedly in spite of the backgrounds of p53 gene in cells