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TFAM — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yoshida et al., Cancer Res 2003
:
Binding of
mtTFA to cisplatin modified DNA was significantly
enhanced by
p53 , whereas binding to oxidized DNA was inhibited
Park et al., Circ Res 2009
:
These in vivo observations were further supported by in vitro studies showing overexpression of
p53 in mouse myoblasts
increases both
TFAM and mtDNA levels whereas depletion of TFAM by shRNA decreases mtDNA content