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MUC1 — TP53

Pathways - manually collected, often from reviews:

• FastForward regulation: MUC1 → TP53 (transcriptional regulation, decrease) Wei et al., Cancer Res 2007*
  Evidence: REG, PROMACTIVITY, DNABINDING

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: MUC1 — TP53 (coimmunoprecipitation) Wei et al., Cancer Cell 2005*
• IRef Bind_translation Interaction: MUC1 — TP53 (affinity chromatography technology) Wei et al., Cancer Cell 2005*
• IRef Biogrid Interaction: TP53 — MUC1 (physical association, affinity chromatography technology) Wei et al., Cancer Cell 2005*
• IRef Biogrid Interaction: TP53 — MUC1 (direct interaction, pull down) Wei et al., Cancer Cell 2005*
• IRef Biogrid Interaction: TP53 — MUC1 (colocalization, imaging technique) Wei et al., Cancer Cell 2005*

Text-mined interactions from Literome

Wei et al., Cancer Cell 2005 : These findings indicate that MUC1 regulates p53-responsive genes and thereby cell fate in the genotoxic stress response
Wei et al., Cancer Res 2007 (Breast Neoplasms) : The present studies show that MUC1 represses activation of the p53 gene and that MUC1-C occupies the PE21 element in the p53 proximal promoter ... The results also show that MUC1-C increases the recruitment of histone deacetylases 1/3, deacetylation of core histones, and repression of p53 transcription
Singh et al., J Biol Chem 2008 : Phosphorylation of MUC1CT by Met enhanced its interaction with p53 , which led to suppression of AP1 transcription factor activity through interactions at the MMP1 promoter, ultimately leading to reduced transcription of MMP1