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EIF4EBP1 — TP53

Text-mined interactions from Literome

Constantinou et al., Oncogene 2005 : Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53 ... Activation of a temperature-sensitive form of mouse p53 in murine erythroleukaemia cells rapidly inhibits protein synthesis and causes early dephosphorylation and cleavage of protein synthesis initiation factor eIF4GI and the eIF4E binding protein 4E-BP1
Constantinou et al., Biol Cell 2008 (Leukemia, Erythroblastic, Acute) : We now report that activation of p53 also results in modification of 4E-BP1 to a truncated form ... Inhibitor studies indicate that the p53 induced cleavage of 4E-BP1 is mediated by the proteasome and is blocked by conditions that inhibit the dephosphorylation of full-length 4E-BP1