Gene interactions and pathways from curated databases and text-mining

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CXCL8 — TP53

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: TP53 → CXCL8 (decreases, CXCL8 Activity)
    Evidence: IL-8, for example, has been shown to be pro-oncogenic, such as releasing BCL-2, but also suppresses oncogenes, such as p53, hence minimizing apoptosis while inducing cell transformation.