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CKAP4 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Davison et al., J Biol Chem 1999
:
In vivo co-transfection assays of the ability of p53 and its homologues to activate reporter genes showed that a DNA binding mutant of
p53 was not able to act in a dominant negative manner over wild-type p73 or p63 but that a p73 mutant could
inhibit the activity of wild-type
p63
Dohn et al., Oncogene 2001
:
We have found that
p63alpha and DeltaNp63alpha can differentially
regulate endogenous
p53 target genes and induce cell cycle arrest and apoptosis
Vayssade et al., Biochem Pharmacol 2002
(Breast Neoplasms) :
We conclude that, in response to VCR treatment : ( 1 )
p53 is markedly
induced in MCF7 cells, with the same extent than after DNA damaging drugs treatments ; and ( 2 )
p63 is not involved, while p73 expression is down-regulated regardless of the p53 status of the cell lines
Serber et al., Mol Cell Biol 2002
:
Based on this mechanism, we provide a model that explains the transactivation potential of homo- and heterotetramers composed of different
p63 isoforms and their
effect on
p53
Harmes et al., Oncogene 2003
:
Positive and negative regulation of deltaN-p63 promoter activity by p53 and
deltaN-p63-alpha contributes to differential regulation of
p53 target genes
Li et al., Oncogene 2006
:
Here, we present data indicating that, prolonged loss of
p53 leads to the activation of a p53 independent mechanism for transcriptional regulation of
DeltaN-p63 ... Consistent with this observation, we demonstrate that loss of
p53 leads to the stabilization of
TA-p63-gamma that is reversible by ectopic p53
Jacobs et al., Neuron 2005
:
While both TAp63 and p53 induce similar apoptotic signaling proteins and require BAX expression and function for their effects, TAp63 induces neuronal death in the absence of p53, but
p53 requires coincident
p63 expression for its proapoptotic actions
Boldrup et al., J Pathol 2007
(Carcinoma, Squamous Cell...) :
p63 can activate or
repress transcription of
p53 and p73 target genes, but also has unique transcriptional targets and, unlike other p53 family members, is required for normal development and differentiation of squamous epithelia
Hara et al., Mol Med Report 2008
:
No diffuse expression of
p63 was
detected , although diffuse expression of
p53 was detected in 50.0 % ( 12/24 ) of the adenocarcinomas
Liu et al., Mol Cell Biol 2011
(Neoplasms) :
TopBP1 also facilitates mutant
p53 interaction with and
inhibition of the transcriptional activities of
p63/p73
Matin et al., J Exp Med 2013
(Melanoma...) :
Our data provide evidence of a physiological interaction between p63 with p53 whereby translocation of p63 to the mitochondria occurred through a codependent process with p53, whereas accumulation of
p53 in the nucleus was
prevented by
p63