UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

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IRAK2 — TOLLIP

Pathways - manually collected, often from reviews:

BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → TOLLIP (modification, collaborate)
BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
BioCarta signal transduction through il1r: TOLLIP → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
BioCarta signal transduction through il1r: IL-1-alpha (IL1A) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
BioCarta signal transduction through il1r: MYD88 → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
BioCarta signal transduction through il1r: IL-1RAcP (IL1RAP) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
BioCarta signal transduction through il1r: IL-1RA (IL1RN) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, inhibits)
BioCarta signal transduction through il1r: IL-1R (IL1R1) → IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
BioCarta signal transduction through il1r: IL-1-alpha/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1A-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → TRAF6 (modification, activates)
BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → TOLLIP (modification, collaborate)
BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
BioCarta signal transduction through il1r: TOLLIP → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
BioCarta signal transduction through il1r: MYD88 → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1RAcP (IL1RAP) (modification, collaborate)
BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1-beta (IL1B) (modification, collaborate)
BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1R (IL1R1) (modification, collaborate)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Biogrid Interaction: IRAK2 — TOLLIP (physical association, affinity chromatography technology) Li et al., Immunity 2011
IRef Biogrid Interaction: IRAK2 — TOLLIP (direct interaction, pull down) Li et al., Immunity 2011
IRef Intact Interaction: IRAK2 — TOLLIP (physical association, anti tag coimmunoprecipitation) Li et al., Immunity 2011
IRef Intact Interaction: Complex of 20 proteins (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011