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IL1B — TOLLIP

Pathways - manually collected, often from reviews:

• BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: TOLLIP → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: TOLLIP → IL-1-beta (IL1B) (modification, collaborate)
• BioCarta signal transduction through il1r: MYD88 → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  
• BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1RAcP (IL1RAP) (modification, collaborate)
• BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1-beta (IL1B) (modification, collaborate)
• BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1R (IL1R1) (modification, collaborate)
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IRAK/TOLLIP complex (IRAK1-TOLLIP) (modification, collaborate)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4 complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAK/TOLLIP complex (IRAK1-TOLLIP) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, collaborate)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IRAKM (IRAK3) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) (modification, inhibits)
  Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., Cell 2002, Burns et al., J Exp Med 2003, Wesche et al., Immunity 1997
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → TRAF6 (TRAF6) (modification, collaborate) Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IRAK/TRAF6 complex (IRAK1-TRAF6) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/IRAK/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-IRAK1-TOLLIP) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: TRAF6 (TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL1-mediated signaling events: IRAK/TRAF6 complex (IRAK1-TRAF6) → IL1 beta fragment/IL1R1/IL1RAP/MYD88/IRAK4/TOLLIP complex (IL1B-IL1R1-IL1RAP-MYD88-IRAK4-TOLLIP) (modification, collaborate)
  Li et al., Proc Natl Acad Sci U S A 2001, Jiang et al., Mol Cell Biol 2002, Cao et al., Nature 1996
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: IL1B → TOLLIP (reaction) Burns et al., Nat Cell Biol 2000, Li et al., Proc Natl Acad Sci U S A 2002, Kollewe et al., J Biol Chem 2004, Gottipati et al., Cell Signal 2008
• Reactome Reaction: IL1B → TOLLIP (indirect_complex) Burns et al., Nat Cell Biol 2000, Cheng et al., Biochem Biophys Res Commun 2007

Text-mined interactions from Literome

Didierlaurent et al., Mol Cell Biol 2006 : Tollip therefore controls the magnitude of inflammatory cytokine production in response to IL-1beta and LPS
Hu et al., Frontiers in bioscience (Landmark edition) 2009 (Cardiomegaly) : In vitro experiments showed that IL-1beta stimulation also significantly reduced the association of Tollip with IRAK-1 and increased NF-kappaB binding activity in neonatal cardiomyocytes