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TNK2 — WWOX

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: TNK2 — WWOX (physical association, affinity chromatography technology) Mahajan et al., Cancer Res 2005*
• IRef Biogrid Interaction: TNK2 — WWOX (direct interaction, pull down) Chan et al., J Biol Chem 2009
• IRef Hprd Interaction: WWOX — TNK2 (in vivo) Mahajan et al., Cancer Res 2005*

Text-mined interactions from Literome

Mahajan et al., Cancer Res 2005 (Cell Transformation, Neoplastic...) : Taken together, these data indicate that Ack1 stimulated prostate tumorigenesis in part by negatively regulating the proapoptotic tumor suppressor, Wwox
Mahajan et al., J Cell Physiol 2010 : In contrast to AR and AKT, Ack1 mediated phosphorylation of the tumor suppressor Wwox at Tyr287 lead to rapid Wwox polyubiquitination followed by degradation