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Gorelik et al., J Immunol 2004
:
Herein we demonstrate that
B cell activating factor of the TNF family ( BAFF ), a B cell survival factor, also
regulates CD21/35 and
CD23 expression ...
BAFF blockade in wild-type mice down-modulates CD21/35 and CD23 on B cells while survival remains intact, and BAFF exposure
causes elevated CD21/35 and
CD23 expression
Debnath et al., Mol Immunol 2007
:
Analysis of the regulatory
role of
BAFF in controlling the expression of CD21 and
CD23 ... A key question we address in this report is if
BAFF signaling directly
induces CD21 and
CD23 gene transcription and expression at this B cell transition point, or if their expression is simply coincident with B cell maturation and differentiation ... We present data that supports the contention that
BAFF does not preferentially
induce the expression of
CD23 or CD21 at the T1 to T2 transition, nor does exogenous BAFF lead to preferential increased expression of these proteins/genes in mature B cell populations