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MED1 — TNFSF11

Text-mined interactions from Literome

Liu et al., J Biol Chem 2003 : Moreover, the binding is significantly enhanced in EMSA with nuclear extracts from RANKL treated RAW264.7 cells and BMMs, suggesting that the 12-bp sequence may be involved in RANKL induced TRAP transcription ... Importantly, mutation of the USF binding site partially blocks RANKL induced TRAP transcription in RAW264.7 cells, confirming that USF1 and USF2 are functionally involved in RANKL induced TRAP transcription
Shi et al., Gene 2004 : Functionally, mutation of the YY1 binding site resulted in a reduction in the RANKL induced TRAP transcription in RAW264.7 cells, demonstrating that YY1 positively regulates RANKL induced TRAP transcriptional activation
Ariyoshi et al., J Cell Biochem 2008 (Bone Resorption) : Heparin suppressed TRAP positive multinucleated cell formation and TRAP activity induced by RANKL , whereas the other GAGs showed no effects on osteoclast differentiation
Kim et al., J Cell Physiol 2009 (Bone Resorption) : We found that saurolactam was one of the compounds inhibiting the RANKL induced osteoclastogenesis ; it significantly inhibited the RANKL induced TRAP activity and formation of multinucleated osteoclasts without any cytotoxicity
Konda et al., Journal of inflammation (London, England) 2009 : The inhibitory effect of RIAA on inflammatory markers was assessed by measuring nitric oxide in LPS stimulated RAW 264.7 cells, RANKL mediated TRAP activity in transformed osteoclasts, and TNF-alpha/IL-1beta mediated MMP-13 expression in SW1353 cells ... In addition, RIAA inhibited NF-kappaB mediated inflammatory markers in various cell models, including nitric oxide in LPS stimulated RAW 264.7 cells, RANKL mediated TRAP activity in transformed osteoclasts, and TNF-alpha/IL-1beta mediated MMP-13 expression in SW1353 human chondrosarcoma cells
Mazière et al., J Cell Physiol 2009 (Bone Resorption) : Finally, OxLDL also prevented RANKL induced TRAP activity and RANKL induced bone resorbing activity of human peripheral blood mononuclear cells
Franco et al., Exp Cell Res 2011 (Bone Resorption) : Furthermore, MMP-9 enzyme inhibitor also attenuated both RANKL induced osteoclastogenesis and up-regulation of TRAP and cathepsin K mRNA expression, indicating that MMP-9 enzyme action is engaged in the promotion of RANKL induced osteoclastogenesis ... Finally, Dox treatment abrogated RANKL induced osteoclastogenesis and TRAP activity in mouse calvaria along with the suppression of MMP9 enzyme activity, again without affecting the expression of MMP9 protein
Zhang et al., Biochimie 2012 (Bone Resorption) : Besides, RANKL induced osteoclast formation from RAW 264.7 cells and the expression of TRAP , CA II, CTSK and MMP-9 was significantly reduced by the treatment of 25 µM HEF and 17ß-estradiol ( ES ), and the inhibitory strength increases in the order TF < ES < ICA < BS, which was blocked by ICI182780 suggesting that the regulation of osteoclast activity might be ER dependent
Naidu et al., Chem Biol Interact 2013 (Arthritis, Experimental...) : The peptide YR-11 ( YLEIEFSLKHR ), obtained by direct substitution of cysteine with a serine residue in the template sequence, significantly ( p < 0.05 ) inhibited RANK-RANKL binding, and RANKL induced TRAP activity and formation of multinucleated osteoclasts without any cytotoxicity
Liou et al., PloS one 2013 (Osteoporosis) : In addition, KMUP-1 inhibited RANKL induced activation of signaling molecules ( Akt, MAPKs, calcium and NF-?B ), mRNA expression of osteoclastogensis associated genes ( TRAP , MMP-9, Fra-1, and cathepsin K ) and transcription factors ( c-Fos and NFATc1 )