Roccisana et al., J Biol Chem 2004
:
In addition, overexpression of HSF-2 in SAKA-T cells resulted in a 5-fold increase in the levels of RANKL expression in these cells
Bai et al., J Biol Chem 2005
(Bone Resorption) :
In human MG63 cells, however, we found that ROS promoted heat shock factor 2 (HSF2) binding to heat shock element in human RANKL promoter region and that HSF2 , but not PKA, was required for ROS up-regulation of RANKL as revealed by KT5720 and HSF2 RNA interference transfection
Kajiya et al., J Cell Biochem 2006
:
We have recently demonstrated a functional role for heat shock factor-2 (HSF-2) in fibroblast growth factor-2 (FGF-2) induced RANK ligand (RANKL) , a critical osteoclastogenic factor expression on stromal/preosteoblast cells ... These data further confirm that HSF-2 plays an important role in FGF-2 induced RANKL expression in stromal/preosteoblast cells