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SYT1 — TNF

Text-mined interactions from Literome

Chêne et al., J Virol 1999 : TNF is the major inducer of NF-kappaB and particularly of the p50-p65 complex, whereas IL-7 acts as a cofactor by sustaining the expression of the p75 TNF receptor
Kurokouchi et al., J Bone Miner Res 2000 : Western blot and immunocytochemical analyses showed that Dex attenuated the TNF-alpha induced nuclear translocation of p65
Kurokouchi et al., J Biol Chem 2001 : We found that OFF inhibits NF-kappaB-DNA binding activities, especially TNF-alpha induced p50-p65 heterodimer NF-kappaB activation and TNF-alpha induced intercellular adhesion molecule-1 mRNA expression
Sakai et al., J Bone Miner Res 2001 : Treatment with proteasome inhibitors inhibited the degradation of both IkappaB-alpha and IkappaB-beta and prevented the TNF-alpha dependent nuclear translocation of p65
Ginis et al., Mol Med 2000 : H2O2 inhibited TNFalpha induced accumulation of p65 in the nucleus, although it had no effect on degradation of the IkappaB in cytoplasm
Voisard et al., BMC molecular biology 2001 : We hypothesized that tumor necrosis factor-alpha (TNF-alpha) induced and NF-kappaB mediated expression of intercellular adhesion molecule-1 ( ICAM-1 ) can be inhibited by antisense RelA p65 and NF-kappaB1 p50 oligonucleotides ( RelA p65 and NF-kappaB1 p50 )
Chen et al., Br J Pharmacol 2002 : 5. Taken together, these data demonstrate that magnolol inhibits TNF-alpha induced nuclear translocation of NF-kappa B p65 and thereby suppresses expression of VCAM-1, resulting in reduced adhesion of leukocytes
Jana et al., J Neurochem 2002 : Consistently, a dominant negative mutant of p65 ( Delta ( p65 ) ) and that of C/EBPbeta ( DeltaC/EBPbeta ) inhibited the expression of TNF-alpha in BV-2 microglial cells stimulated with the combination of IFN-gamma and CD40 ligand
Mayo et al., J Biol Chem 2002 : PTEN failed to block TNF induced IKK activation, IkappaBalpha degradation, p105 processing, p65 ( RelA ) nuclear translocation, and DNA binding of NF-kappaB
Kim et al., J Cell Biochem 2002 : Conversely, expression of the p65 subunit of NF-kappaB suppressed TNF-alpha- , TRAIL-, and serum deprivation induced cell death
Lagow et al., J Cell Biochem 2002 (Breast Neoplasms) : Binding of NFkappaB p65 to the MUC1 kappaB site was induced by TNF-alpha treatment, as demonstrated by electrophoretic mobility shift assay
Ashikawa et al., J Immunol 2002 : When examined for the mechanism, we found that piceatannol inhibited TNF induced IkappaBalpha phosphorylation, p65 phosphorylation, p65 nuclear translocation, and IkappaBalpha kinase activation, but had no significant effect on IkappaBalpha degradation
Chen et al., Br J Pharmacol 2003 : Neither calphostin C nor PD98059 affected TNF-alpha induced degradation of I-kappaBalpha or p65 nuclear translocation ... ( 5 ) Pretreatment with pentoxifylline ( 0.1-1 mg ml(-1) ) decreased TNF-alpha stimulated fractalkine mRNA and protein expression, which was preceded by a reduction in TNF-alpha activated phosphorylation of PKC, p42/44 MAPK and c-Jun as well as degradation of I-kappaBalpha and p65/NF-kappaB nuclear translocation
Zernecke et al., FASEB J 2003 : Only at high concentrations, cPG enhanced TNF-alpha induced cell death and inhibited TNF-alpha induced IkappaB-alpha kinase (IKK) activation, IkappaB-alpha degradation, and NF-kappaB/p65 translocation, while promoting AP-1/c-jun phosphorylation
Pellegatta et al., Am J Clin Nutr 2003 : The nuclear appearance of p50-NFkappaB and p65-NFkappaB acutely induced by TNF-alpha was not modified by resveratrol but was increased after overnight incubation with resveratrol alone or in combination with TNF-alpha
Chang et al., Diabetes 2003 (Cell Transformation, Viral...) : TNF-alpha induced inhibitor of kappaB ( IkappaB ) degradation and p65 translocation from cytoplasm to nuclei in MIN6N8 insulinoma cells
Sakurai et al., J Biol Chem 2003 : Tumor necrosis factor-alpha induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
Papin et al., J Biol Chem 2003 (Familial Mediterranean Fever) : The tumor necrosis factor alpha dependent activation of the human mediterranean fever (MEFV) promoter is mediated by a synergistic interaction between C/EBP beta and NF kappaB p65
O'Connor et al., J Immunol 2003 : Furthermore, CIAS1 suppressed TNF-alpha induced nuclear translocation of endogenous p65
Migita et al., FEBS Lett 2004 : Overexpression of RORalpha1 and RORalpha4 also suppressed TNF-alpha stimulated translocation of p50 and p65 to the nucleus
Son et al., Endocrinology 2004 : TNF rapidly increased p65 in OV3121-1 nuclei when compared with controls not treated with TNF
Sarkar et al., J Biol Chem 2004 (Breast Neoplasms...) : In addition, mangiferin inhibits TNF induced p65 phosphorylation as well as translocation to the nucleus and also inhibits NF-kappaB activation induced by other inflammatory agents like PMA, ceramide, and SA-LPS
Hu et al., Carcinogenesis 2004 (Cell Transformation, Neoplastic) : Here we show that TNF-alpha induces greater ERK dependent p65 phosphorylation at S536 in transformation sensitive ( P+ ) cells than in P- cells
Das et al., J Biol Chem 2005 : Tpl2 transduced TNF-alpha signals instead promote the phosphorylation of p65 at Ser276 and modulate the spectrum of proteins associated with p65
Chiu et al., J Biomed Sci 2005 : Pre shearing of ECs at HSS significantly inhibited the TNF-alpha induced p65 and p50 mRNA expressions and nuclear factor-kappaB (NF-kappaB)-DNA binding activity
Hall et al., Am J Physiol Heart Circ Physiol 2005 : Therefore, the goal of the present study was to examine the role of p65 subunit phosphorylation in the regulation of TNF-alpha production in cultured neonatal ventricular myocytes
Yasui et al., Cancer Res 2005 (Multiple Myeloma) : Finally, it down-regulates interleukin-6 induced phosphorylation of Akt, signal transducers and activators of transcription 3, and p42/44 mitogen activated protein kinase ; insulin-like growth factor-I triggered Akt phosphorylation ; and tumor necrosis factor alpha induced IkappaBalpha and nuclear factor-kappaB p65 phosphorylation
Lora et al., J Biol Chem 2005 (Cystic Fibrosis) : TNF-alpha stimulation induced IKKbeta dependent p65 nuclear translocation, mucus synthesis, and production of cytokines from epithelial cells
Aggarwal et al., Mol Pharmacol 2006 (Neoplasm Metastasis) : We found that curcumin suppressed TNF induced nuclear translocation of p65 , which corresponded with the sequential suppression of IkappaBalpha kinase activity, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and p65 acetylation
Kang et al., Eur J Pharmacol 2005 : PGG treatment attenuated tumor necrosis factor-alpha (TNF-alpha) induced nuclear factor-kappaB (NF-kappaB) p65 translocation in human umbilical vein endothelial cells
Moon et al., Life Sci 2006 : AR treatment attenuated TNF-alpha induced NF-kappaB p65 translocation in HUVECs in a dose dependent manner
Gomez et al., J Immunol 2005 (Arthritis, Rheumatoid...) : IL-1beta/TNF-alpha stimulated the translocation of p65 and p50 from the cytosol to the nucleus of human RA synovial fibroblasts, as well as NF-kappaB activation measured by luciferase reporter assay
Takada et al., J Biol Chem 2006 (Neoplasm Invasiveness) : We also found that SAHA had no effect on direct binding of NF-kappaB to the DNA but inhibited sequentially the TNF induced activation of IkappaBalpha kinase, IkappaBalpha phosphorylation, IkappaBalpha ubiquitination, IkappaBalpha degradation, p65 phosphorylation, and p65 nuclear translocation
Takada et al., J Immunol 2006 : AKBA did not directly affect the binding of NF-kappaB to the DNA but inhibited sequentially the TNF induced activation of IkappaBalpha kinase (IKK), IkappaBalpha phosphorylation, IkappaBalpha ubiquitination, IkappaBalpha degradation, p65 phosphorylation, and p65 nuclear translocation
Wang et al., Biol Pharm Bull 2006 (Carcinoma, Hepatocellular...) : Western blot revealed that the treatment of Huh 7 cells with pitavastatin at 0.1 microM inhibited the nuclear expression of NF-kappaB p65 induced by TNF-alpha
Issa et al., Am J Physiol Lung Cell Mol Physiol 2006 (MAP Kinase Signaling System) : By chromatin immunoprecipitation assay, IL-1beta and TNF-alpha enhanced p65 binding to the GRO-alpha promoter, which was inhibited by AS-602868
Sandur et al., J Biol Chem 2006 (Inflammation) : The suppression of NF-kappaB activation correlated with sequential inhibition of the tumor necrosis factor (TNF) induced activation of IkappaBalpha kinase, IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation, p65 nuclear translocation, and the NF-kappaB dependent reporter gene expression activated by TNF, TNFR1, TRAF2, NIK, IKK-beta, and the p65 subunit of NF-kappaB
Zwergal et al., J Immunol 2006 : Furthermore, in tolerant cells, TNF induced NF-kappaB p65 phosphorylation was markedly decreased, which was accompanied by the formation of C/EBPbeta-p65 complexes
Luo et al., Am J Physiol Cell Physiol 2007 : SIMPL mutants lacking sites of TNF-alpha enhanced phosphorylation impaired nuclear localization and prevented TNF-alpha induced p65 transactivation activity
Sompol et al., J Mol Neurosci 2006 (Neuroblastoma) : In the present study, we demonstrate that TNF-alpha activates NF-kappaB activity in neuronal, SH-SY5Y, cells and preferentially enhances the binding of p50 and p65 to the promoter/enhancer regions of the MnSOD gene
Higai et al., Biol Pharm Bull 2006 (Adenocarcinoma...) : TNFalpha stimulation induced the biphasic increases in expression of NFkappaB-p65 , ST3Gal I, FUT IV, ST3Gal IV and ST6GalNAc III mRNAs and the transient increase in expression of ST6Gal I mRNA and the decrease in ST3GalNAc IV mRNA
Qin et al., Glia 2007 (Disease Models, Animal...) : Systemic TNFalpha and LPS administration activated microglia and increased expression of brain pro-inflammatory factors ( i.e., TNFalpha, MCP-1, IL-1beta, and NF-kappaB p65 ) in wild-type mice, but not in TNF R1/R2 ( -/- ) mice
Nakabe et al., Int J Hyperthermia 2007 (Fever) : Furthermore, Western blotting analysis revealed that pretreatment of hyperthermia attenuated TNF-alpha induced translocation of p65 into the nuclei of HAEC
Laga et al., Biochem Pharmacol 2007 : The TNF induced nuclear translocation of NF-kappaB p65 was also delayed, but not inhibited, in the presence of methylglyoxal ... TNF induced phosphorylation of p65 was not affected by methylglyoxal
Liu et al., J Immunol 2007 : The intronic NF-kappaB sequences in combination with the promoter or alone regulated the expression of a luciferase reporter gene in response to TNF-alpha stimulation or overexpression of NF-kappaB p65 and p50
Kang et al., Biol Pharm Bull 2007 : Cornuside treatment attenuated tumor necrosis factor-alpha (TNF-alpha) induced nuclear factor-kappa B (NF-kappaB) p65 translocation in HUVECs
Sasaki et al., Cancer Res 2007 : Furthermore, tumor necrosis factor (TNF) treatment slightly induced p65 phosphorylation, and both unphosphorylated and phosphorylated p65 translocated into the nucleus
Kim et al., Biochem Biophys Res Commun 2008 : Pretreatment of EPA inhibited TNF-alpha induced MMP-9 expression and p65 phosphorylation ... EPA inhibited TNF-alpha induced p65 phosphorylation through p38 and Akt inhibition and this inhibition was IKKalpha dependent event
Kimura et al., Invest Ophthalmol Vis Sci 2008 : TNF-alpha induced the phosphorylation and downregulation of IkappaB-alpha and the translocation of the p65 subunit of NF-kappaB to the nucleus
Yu et al., Br J Nutr 2008 (Atherosclerosis) : Furthermore, the production of reactive oxygen species and the nuclear translocation of NF-kappaB p50 and p65 induced by TNF-alpha were dose-dependently suppressed by CA pretreament
Hung et al., Eur J Pharmacol 2008 : A further analysis indicated that lycopene attenuated TNF-alpha induced IkappaB phosphorylation, NF-kappaB expression, and NF-kappaB p65 translocation from cytosol to nucleus
Young et al., J Invest Dermatol 2008 (Psoriasis...) : Employing a series of in vitro and in cellulo approaches, we have demonstrated that in primary human keratinocytes ( i ) TNF-alpha rapidly induces ROS generation, IkappaB degradation, NF-kappaB p65 nuclear translocation, and ultimately production of inflammatory cytokines ; ( ii ) TNF-alpha induced cytokine production is mediated both by the mammalian target of rapamycin signaling pathway via NF-kappaB activation and by ROS ; ( iii ) TNF-alpha dependent NF-kappaB activation ( that is, IkappaB degradation and NF-kappaB p65 nuclear translocation ) is not mediated by ROS ; and ( iv ) a cell penetrating derivative of the antioxidant enzyme, catalase, as well as taurine and N-acetyl-cysteine attenuate the TNF-alpha induced production of cytokines
Joo et al., Biol Pharm Bull 2008 (Inflammation...) : Rg3 effectively reduced inflammatory cytokine expression in Abeta42 treated BV-2, and inhibited the binding of NF-kappaB p65 to its DNA consensus sequences, and significantly reduced the expression of TNF-alpha in activated microglia
Böcker et al., J Mol Med (Berl) 2008 : Stimulation of hMSCs with TNF-alpha caused a p65 translocation from the cytoplasm to nucleoplasm but did not change the expression profile of MSC markers
Cao et al., Inflammation 2009 (Inflammation) : Pep 3 ( LRENECVS ) which was derived from the hydrophilic region of A1 module in CRD4 remarkably inhibited the binding of TNF-alpha to TNF-R1, and also reversed TNF-alpha induced degradation of IkappaB-alpha and nuclear translocation of NF-kappaB p65 subunit in HeLa cells
Uhl et al., Viral Immunol 2009 (Asthma...) : Furthermore, direct inhibition of TNF-alpha also increases pulmonary expression of p65 in virus infected BN, but not F344, rats
Wu et al., American journal of physiology. Renal physiology 2009 (Nephritis) : TNF caused translocation of the p65 subunit of NF-kappaB to the nucleus, resulting in upregulation of inflammatory markers such as adhesion molecules ICAM-1 and VCAM-1
Yu et al., Nutr Metab Cardiovasc Dis 2010 : Furthermore, the production of ROS and the nuclear translocation of NF-kappaB p50 and p65 induced by TNF-alpha were dose-dependently suppressed by curcumin pretreatment
Lu et al., Cancer Res 2009 : Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha
Cheng et al., Infect Immun 2009 (Inflammation) : While activation of NF-kappaB was essential for heat inactivated S. aureus induced TNF-alpha and NO, inhibiting GSK-3beta blocked heat inactivated S. aureus induced NF-kappaB p65 nuclear translocation
Theiss et al., Mol Biol Cell 2009 (Adenocarcinoma...) : Sustained expression of prohibitin in intestinal epithelial cells in vitro and in vivo ( prohibitin transgenic mice, PHB TG ) resulted in a marked decrease in TNF-alpha induced nuclear translocation of the NF-kappaB protein p65 , NF-kappaB/DNA binding, and NF-kappaB mediated transcriptional activation despite robust IkappaB-alpha phosphorylation and degradation and increased cytosolic p65
Park et al., Mol Cells 2009 : We further showed that only LHDAg but not SHDAg increased the TNF-alpha mediated nuclear translocation of p65
John et al., J Immunol 2009 (Asthma) : Furthermore, chromatin immunoprecipitation studies detected increased binding of NF-kappaB p65 and RNA polymerase II to the CXCL8 promoter of asthmatic HASM cells both in the presence and absence of TNF-alpha stimulation
Gossye et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid) : In sharp contrast, DEX did not affect TNFalpha induced IKK phosphorylation, IkappaBalpha degradation, p65 nuclear translocation, or MAPK activation in RA FLS
Gong et al., J Am Soc Nephrol 2010 : Despite normal IkBalpha degradation and polyubiquitination, FAT10 deficiency impaired TNF-alpha induced IkBalpha degradation and nuclear translocation of p65 in RTECs, suggesting defective proteasomal degradation of polyubiquitinated IkBalpha ... Transduction of FAT10 ( -/- ) RTECs with FAT10 restored LMP2 expression, TNF-alpha induced IkBalpha degradation, p65 nuclear translocation, and NF-kappaB activation
Wu et al., Gynecol Obstet Invest 2010 (Endometriosis) : TSA also attenuated constitutive and TNF dependent p65 phosphorylation and nuclear translocation in endometriotic cells
Lee et al., J Cell Physiol 2010 (MAP Kinase Signaling System) : We also showed that TNF-alpha induced Akt translocation and the formation of an Akt/p65/p300 complex
Xu et al., Eur J Pharmacol 2010 (Inflammation) : In addition, icariin suppressed the secretion of TNF-alpha , prostaglandin E2 ( PGE ( 2 ) ) and nitric oxide ( NO ) as well as NF-kappaB p65 activation
Tyagi et al., Mol Cell Endocrinol 2010 : In calvarial osteoblasts, medicarpin ( 10 ( -10 ) M ) blocked nuclear factor kappaB (NF-kappaB) signaling assessed by tumor necrosis factor alpha (TNFalpha) stimulated nuclear translocation of p65 subunit of NF-kappaB
Lee et al., Phytother Res 2010 : In addition, ATO attenuated TNF-a induced p65 NF-?B translocation into the nucleus and phosphorylation of I?B-a
Sasaki et al., J Biol Chem 2011 : The LTß priming process was not due to an increase in TNF mediated nuclear translocation of p65, p65 DNA binding, or NF-?B transactivational activity
Chen et al., Arch Biochem Biophys 2011 (Inflammation) : EMSA and ChIP assays showed that TNF-a increased p50/p65 binding to this ?B site, which was disrupted by 1,25 ( OH ) 2D3
Dai et al., J Biol Chem 2011 (Inflammation) : TGF-ß1 affected neither TNF-a induced I?Ba phosphorylation and subsequent degradation, nor p65 NF-?B phosphorylation and its nuclear translocation
Shukla et al., Carcinogenesis 2011 : The non-IKK-phosphorylable p65-S534A mutant did not induce HBx protein stability ; hence, phosphorylation of p65 by IKK is a key step in TNF-a induced stabilization of HBx. Phospho-p65 showed higher affinity to HBx compared with the non-phosphorylable p65 mutant, suggesting that the interaction of phospho-p65 with HBx might be important for HBx stabilization
Wu et al., J Endocrinol Invest 2012 : TNF-a increases p65 protein level and nuclear factor ?B ( NF-?B ) activity
Ryu et al., Cell Mol Neurobiol 2011 (Status Epilepticus) : Therefore, these findings suggest that clasmatodendrosis may be autophagic astroglial death in response to epileptic seizures through TNF-a mediated p65/RelA-Ser529 phosphorylation
Kim et al., Journal of neuroinflammation 2012 (Brain Edema...) : These findings suggest that impairments of endothelial cell functions via TNF-a mediated p65-Thr 485 NF-?B phosphorylation may be involved in SE-induced vasogenic edema
Kim et al., Phytother Res 2012 : The results were as follows : ( i ) silibinin inhibited the expression of the MUC5AC mucin gene induced by EGF, PMA or TNF-a from NCI-H292 cells ; ( ii ) silibinin also inhibited the production of MUC5AC mucin protein induced by the same inducers from NCI-H292 cells ; ( iii ) silibinin inhibited the activation of NF-?B p65 by TNF-a in NCI-H292 cells ; ( iv ) silibinin significantly decreased ATP induced mucin secretion from cultured RTSE cells
Hu et al., Zhongguo Zhong Yao Za Zhi 2012 (Carcinoma, Non-Small-Cell Lung) : Immunocytochemistry results revealed luteolin can inhibit TNF-alpha stimulated p65 from nuclear translocation as a transcription factor and thus promoting cell apoptosis
Yang et al., J Nutr Biochem 2013 (Inflammation) : Transfection with HO-1 siRNA knocked down HO-1 expression and partially reversed the DHA mediated inhibition of TNF-a induced p65 nuclear translocation and ICAM-1 expression
Xing et al., Pharm Biol 2013 : In addition, the effects of total flavonoids on inflammatory molecule expression of cells were tested by immunohistochemistry staining, showing that TNF-a induced expression of PCNA, NF-?B p65 , ICAM-1, and VCAM-1 in VSMCs was dose-dependently suppressed by total flavonoids
Balwani et al., PloS one 2012 : In human umbilical vein endothelial cells ( HUVECs ), TNF-a induced I?Ba degradation and p65/RelA phosphorylation regulate NF-?B activation
Arbab et al., Evidence-based complementary and alternative medicine : eCAM 2012 : In addition, we found that dentatin inhibited TNF-a induced nuclear translocation of p65 , suggesting dentatin as a potential NF-?B inhibitor
Ren et al., Int Immunopharmacol 2012 : Although cordycepin did not block TNF-a induced nuclear translocation of p65 , high concentration of cordycepin reduced the DNA binding and transcriptional activities of NF-?B
Zhao et al., PloS one 2013 : SIMPL enhancement of tumor necrosis factor-a dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function
Cheng et al., J Immunol 2013 (MAP Kinase Signaling System) : Exogenous GILZ inhibited TNF induced NF-?B p65 DNA binding, although this occurred in the absence of an effect on p65 nuclear translocation, indicating that the mechanism of action of exogenous GILZ in endothelial cells differs from that reported in other cell types
Beck et al., PloS one 2013 : With regard to their anti-inflammatory mechanism, heat shock and Compound A are both able to reduce TNF stimulated I?Ba degradation and NF-?B p65 nuclear translocation
Thieblemont et al., J Immunol 1995 (HIV Infections) : TNF-alpha did not mediate the translocation of NF-kappa B p50/p65 induced by triggering of complement receptors
Pimentel-Muiños et al., Eur J Immunol 1995 : TNF-alpha , therefore, emerges as the main factor responsible for a second phase of NF-kappa B regulation, controlling both translocation of p65 and c-rel, and new mRNA synthesis for c-rel and p105/p50
Wu et al., J Biol Chem 1994 : Both p65 transactivation and TNF-alpha induction of the p53 promoter depended on an intact NF-kappa B site
Jahnke et al., Immunobiology 1995 (Melanoma) : Using electrophoretic mobility shift assays and specific antibodies we observed that the NF-kappa B like sequence at -187 bound both p65/p50 and p65/c-Rel in the presence of TNF-alpha , while the interferon responsive region at -75 bound Stat1 alpha ( p91 )
Ollivier et al., J Biol Chem 1996 : Elevated cAMP did not prevent nuclear translocation of p50/p65 and c-Rel/p65 heterodimers, decrease nuclear translocation of p65, or significantly modify TNFalpha induced phosphorylation of p65
Vanden Berghe et al., J Biol Chem 1998 : p38 and extracellular signal regulated kinase mitogen activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor
Manna et al., J Immunol 1998 : Pretreatment of cells with IL-13 blocked TNF induced NF-kappa B activation, nuclear translocation of p65 subunit, and degradation of I kappa B alpha