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LEP — TNF
Text-mined interactions from Literome
Medina et al., Int J Obes Relat Metab Disord 1999
:
TNF-alpha at concentrations of 0.024, 0.24, 2.4 and 24 ng/ml did not
affect leptin secretion over 24 h. TNF-alpha at concentrations of 0.24 to 24 ng/ml significantly inhibited leptin secretion over 96 h by 19-60 % ...
TNF-alpha at a concentration of 0.024 ng/ml did not
affect leptin secretion, glucose uptake or lactate production
Gottschling-Zeller et al., Eur J Endocrinol 1999
:
The aim of this study was to characterize the
role of
tumor necrosis factor (TNF)-alpha and transforming growth factor (TGF)-beta1 in depot-specific secretion of
leptin from cultured human adipocytes ... We measured the leptin concentrations in the culture medium of omental and subcutaneous abdominal adipocytes taken from severely obese individuals and kept in suspension culture, and studied the
effect of
TNF-alpha and TGF-beta1 on
leptin release
Uchida et al., Naunyn Schmiedebergs Arch Pharmacol 1999
:
Protein kinase C mediates
tumor necrosis factor-alpha induced inhibition of obese gene expression and
leptin secretion in brown adipocytes ... To know whether TNF-alpha also affects late events in brown adipocyte maturation, we examined the
effect of
TNF-alpha on obese gene expression and
leptin secretion in mouse brown adipocytes differentiated in culture ...
TNF-alpha caused a concentration dependent decrease in
leptin accumulation in culture medium and leptin mRNA amount in brown adipocytes which constitutively express the ob gene ... Time-course study showed that
TNF-alpha significantly
suppressed leptin secretion during incubation for 16, 24 and 48 h ... Since some effect of TNF-alpha is mediated by activation of protein kinase C ( PKC ), the role of PKC in
TNF-alpha induced downregulation of ob gene expression and
leptin secretion was studied ... The suppressive
effect of
TNF-alpha on both ob gene expression and
leptin secretion was blocked by PKC inhibitors such as bisindolylmaleimide I ( BIM ) and 1- ( 5-isoquinolinesulfonyl ) -2-methylpiperazine dihydrochloride ( H-7 )
Finck et al., Am J Physiol Regul Integr Comp Physiol 2000
:
Tumor necrosis factor (TNF)-alpha induces
leptin production through the p55 TNF receptor ... The results using all four strategies show that the
induction of
leptin production by
TNF-alpha requires activation of the p55 TNFR and that although activation of the p75 TNFR alone can not cause leptin production, its presence affects the capability of TNF-alpha to induce leptin production through the p55 TNFR
Faggioni et al., Proc Natl Acad Sci U S A 2000
(Drug-Induced Liver Injury) :
These results demonstrate that
leptin deficiency
leads to reduced production of
TNF-alpha and IL-18 associated with reduced T cell mediated hepatotoxicity
Zhang et al., Mol Cell Endocrinol 2000
:
The acute and chronic
effects of
tumour necrosis factor-alpha (TNF-alpha) on
leptin production by human preadipocytes, differentiated preadipocytes, and mature adipocytes have been examined by competitive RT-PCR of leptin mRNA and by western blotting ...
TNF-alpha blocked
leptin synthesis during differentiation ... In contrast,
TNF-alpha ( 4-8-h treatment )
resulted in a 4-fold increase in
leptin release ... We conclude that
TNF-alpha stimulates the release of preformed leptin from human mature adipocytes and existing differentiated preadipocytes, which may contribute to obesity/infection linked hyperleptinemia, and that TNF-alpha
inhibits leptin synthesis via inhibition of preadipocyte differentiation and induction of adipocyte dedifferentiation
Finck et al., Microsc Res Tech 2000
(Cachexia...) :
Tumor necrosis factor-alpha regulates secretion of the adipocyte derived cytokine,
leptin
Cakir et al., Horm Res 1999
(Body Weight...) :
Pretreatment serum leptin ( 4.5 +/- 0.9 vs. 2.1 +/- 0.2 ng/ml, respectively ; p < 0.05 ) and plasma
TNFalpha ( 27.9 +/- 3.4 vs. 23.9 +/- 3.0 pg/ml, respectively ; p < 0.05 ) levels of the patients were significantly higher than those of the controls. After treatment, serum
leptin levels
increased to 6.7 +/- 2.2 ng/ml, but this rise was not statistically significant ( p > 0.05 )
Kato et al., Clin Nephrol 2001
(Kidney Diseases) :
The expression of
leptin , an adipocyte derived protein, is
regulated by
tumor necrosis factor-alpha (TNF-alpha)
Mastronardi et al., Proc Natl Acad Sci U S A 2002
(Body Weight) :
Leptin increased
tumor necrosis factor (TNF)-alpha release at a 100-fold lower dose than required for NO release in vitro and in vivo, suggesting that it also may participate in leptin induced NO release ... However, because many molecules of leptin were required to release a molecule of TNF-alpha in vivo and in vitro, we believe that
leptin induced
TNF-alpha release is an associated phenomenon not involved in NO production
Chu et al., Clin Biochem 2002
(Obesity) :
However,
TNF-R1 plays a more significant role in
leptin expression among girls only
Medina et al., Metabolism 2002
(Diabetes Mellitus, Experimental...) :
Since TNF-alpha also induces hyperinsulinemia, and because insulin is a potent stimulator of leptin production, we hypothesized that elevated plasma insulin mediates
TNF-alpha induced increases of circulating
leptin ... In nondiabetic rats,
TNF-alpha increased plasma insulin ( P =.016 ) and
prevented the fasting induced decrease of circulating
leptin ( P =.004 ) over the initial 12 hours compared with vehicle ... These results suggest that TNF-alpha induced hyperinsulinemia likely mediates the stimulatory
effect of
TNF-alpha on circulating
leptin in vivo
Lambert et al., J Gerontol A Biol Sci Med Sci 2003
(Weight Gain) :
IL-6 was reduced by MA except when RT was undertaken
; TNF alpha was
reduced over time regardless of group ;
leptin was higher in individuals not on T than those on T ; and the change in plasma leptin was correlated with the change in fat mass
Gaetke et al., J Am Coll Nutr 2003
(Autoimmune Diseases...) :
The objective of this study was to examine whether increased
tumor necrosis factor-alpha (TNF-alpha) , a pro-inflammatory cytokine,
contributes to the abnormally elevated
leptin in IL-2 ( -/- ) mice
Frisullo et al., J Clin Immunol 2004
(Multiple Sclerosis, Relapsing-Remitting) :
Our data showed that
leptin induced
tumor necrosis factor-alpha , interleukin-6, and interleukin-10 production by PBMCs of patients in an acute phase of disease but not in patients in a stable phase or in healthy controls
Härle et al., Ann Rheum Dis 2004
(Arthritis, Rheumatoid...) :
Leptin is
stimulated by
TNF and is associated with hypoandrogenicity in non-inflammatory conditions
Sato et al., Adv Exp Med Biol 2003
(Anorexia...) :
Tumor Necrosis Factor (TNF) and/or interleukin-1 (IL-1)
stimulate leptin release, but not insulin
Erkasap et al., J Physiol Biochem 2004
(Disease Models, Animal...) :
The purpose of the study was to evaluate the
effects of
leptin on renal tissue
TNF-alpha , malondialdehyde ( MDA ), protein carbonyls ( PCs ) and total sulfydryl group ( SH ) levels, and plasma nitrite levels after renal I/R injury in rats
Franchimont et al., J Clin Endocrinol Metab 2005
(Crohn Disease...) :
The
regulation of
leptin by
TNFalpha is poorly understood in CD ... Pharmacological neutralization of TNFalpha with infliximab offers a unique opportunity to study
TNFalpha mediated regulation of
leptin in CD patients
Sopasakis et al., Int J Obes Relat Metab Disord 2005
:
TNFalpha increased the mRNA levels of TNFalpha itself as well as IL-6, IL-8, IL-1beta and PAI-1, but not
leptin
Shen et al., Life Sci 2005
:
Leptin enhances
TNF-alpha production via p38 and JNK MAPK in LPS stimulated Kupffer cells ... Here we showed the
effects of
leptin on the production of
TNF-alpha ( tumor necrosis factor-alpha ) by Kupffer cells (KCs) with signal transduction ...
Leptin enhanced
TNF-alpha production accompanied by a dose dependent increase of MAPK activity in lipopolysaccharide (LPS) stimulated KCs
Sun et al., Zhonghua Nei Ke Za Zhi 2005
(Diabetes Mellitus, Type 2...) :
Serum levels of TNFalpha and leptin in obese subjects are closely related with insulin resistance, indicating that high level of
TNFalpha may
promote release of
leptin for the modulation of adipocyte
Simons et al., Cytokine 2005
:
However,
TNF-alpha , IL-1beta, and TGF-beta1
stimulated leptin production from preadipocytes in the absence of mature adipocytes ( 20.6+/-5.4 ng/ml, 100.8+/-18.2 ng/ml, and 5.4+/-0.4 ng/ml, respectively, compared to 6.6+/-0.8 ng/ml in control adipocyte cultures on day 21 ; n=4 )
Trujillo et al., J Clin Endocrinol Metab 2006
(Obesity) :
TNF increases plasma
leptin in humans in vivo, but previous studies showed it decreases leptin in vitro ... The objective of this study was to determine the
effect of
TNF on
leptin release from human adipose tissue ( AT ) from healthy subjects undergoing elective surgery or needle aspirations of AT at a university hospital ... In contrast, when added in the presence of dex,
TNF increased secreted
leptin and leptin mRNA abundance in AT from nonobese and obese subjects ... Synergistic effects of increased local or systemic
TNF in combination with glucocorticoids may
contribute to increased
leptin expression in response to stress, including infection and obesity
Zhao et al., Cell Immunol 2005
(MAP Kinase Signaling System) :
Globular adiponectin decreases
leptin induced
tumor necrosis factor-alpha expression by murine macrophages : involvement of cAMP-PKA and MAPK pathways ...
Leptin stimulated
TNF-alpha production at mRNA as well as protein levels in a dose- and time dependent manner ... gAd inhibited
leptin induced
TNF-alpha production through suppressing phosphorylation of ERK1/2 and p38 pathways
Simons et al., J Endocrinol 2007
(Insulin Resistance) :
Despite this reduction of lipid-laden adipocytes,
TNF-alpha , IL-6/sIL-6R, and IL-1beta
stimulated leptin release
Balasubramaniyan et al., Cytokine 2007
:
The aim of our present work was to study the
effect of exogenous
leptin and/or ethanol on the secretion of
TNF-alpha , IL-6 and TGF-beta1 both in vivo and in vitro
Ahmed et al., J Vet Med Sci 2007
:
Leptin treatment
augmented the monocyte/macrophages mRNA expression of only
TNF-alpha and IL-12p40 to comparable levels of cells treated with lipopolysaccharide (LPS)
Rafail et al., Thromb Res 2008
(Inflammation...) :
Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2 dependent mechanisms and
TNFalpha involvement
Sonoda et al., Endocrinology 2008
:
Adiponectin and
leptin , and adipocyte-specific genes of adiponectin, leptin, and PPAR-gamma were
detected in culture assembly, whereas the lipogenesis factor insulin ( 20 mU/ml ) and inflammation related agent
TNF-alpha ( 2 nm ) increased and decreased, respectively, all of their displays
Park et al., Joint Bone Spine 2009
(Spondylitis, Ankylosing) :
Stimulation of PBMCs by exogenous
leptin significantly
increased the production of IL-6 and
TNF-alpha in PBMCs from patients with AS in a dose dependent fashion and these increases were much exacerbated compared to controls
Orlova et al., Bull Exp Biol Med 2009
:
Leptin increased the expression of HLA-DR on T lymphocytes,
stimulated the production of
TNF-alpha and IL-6, and did not affect secretion of IL-2, IL-4, and IL-10 by mononuclear leukocytes
Ryan et al., Pflugers Arch 2010
:
The PPARgamma agonist rosiglitazone stimulated both adiponectin and
leptin expression and
inhibited the expression of IL-6, MCP-1 and
TNFalpha ; MCP-1 secretion was reduced
Kim et al., Journal of periodontal & implant science 2010
:
The purpose of this study was to investigate the
effect of
leptin on Prevotella ( P. ) intermedia lipopolysaccharide (LPS) induced
tumor necrosis factor (TNF)-alpha production in differentiated THP-1 cells, a human monocytic cell line ...
Effect of
leptin on P. intermedia LPS induced
TNF-alpha production was not mediated by the leptin receptor
Herrejón et al., Med Clin (Barc) 2011
(Body Weight...) :
The IL-6 and
TNF alpha levels were not modified in the MA group, but
leptin did
increase ( p < 0.043 )
Kopec-Medrek et al., Rheumatol Int 2012
(Arthritis, Rheumatoid) :
TNF-a was also found to
enhance synthesis of
leptin ... It is possible that
TNF-a induced
leptin secretion contributes to body mass reduction in patients with RA
Jaedicke et al., J Leukoc Biol 2013
:
Additionally,
leptin potentiated Escherichia coli and Porphyromonas gingivalis LPS induced
TNF-a secretion in THP-1 monocytes
Mantzoros et al., J Clin Endocrinol Metab 1997
(Diabetes Mellitus, Type 2) :
The expression of
leptin , an adipocyte derived protein whose circulating levels reflect energy stores, can be
induced by
tumor necrosis factor (TNF)alpha in rodents, but an association between the TNF alpha system and leptin levels has not been reported in humans
Granowitz et al., Biochem Biophys Res Commun 1997
(Inflammation) :
When considered in the context of animal studies showing that interleukin-1 and
tumor necrosis factor-alpha induce
leptin and ob mRNA, these results suggest that pro-inflammatory cytokines induce ob gene transcription in vivo via secondary mediators such as transforming growth factor-beta
Yamaguchi et al., Biochem Biophys Res Commun 1998
:
Moreover, human
TNF-alpha ( h-TNF-alpha ) also
inhibited human-leptin ( h-leptin ) secretion by cultured human adipocytes collected from the subcutaneous fat of pregnant women ... These results suggest that
TNF-alpha , which is secreted by adipocytes,
inhibits m-leptin secretion through mTNF-RI and suggest the presence of an autocrine or paracrine regulation of leptin secretion in human and mouse adipose tissue in vivo
Finck et al., Endocrinology 1998
:
In vivo and in vitro evidence for the
involvement of
tumor necrosis factor-alpha in the induction of
leptin by lipopolysaccharide ... To examine the
role of
tumor necrosis factor-alpha (TNF alpha) in mediating
leptin secretion during an immunological challenge, we studied the effects of lipopolysaccharide (LPS) and TNF alpha on leptin secretion in endotoxin-sensitive C3H/HeOuJ ( OuJ ) mice, endotoxin-insensitive C3H/HeJ ( HeJ ) mice, and primary adipocytes cultured from both ... To determine whether
TNF alpha induces
leptin secretion by acting directly on fat cells, primary adipocytes from OuJ and HeJ mice were cultured in the presence of TNF alpha or LPS
Takahashi et al., J Exp Med 1999
(Inflammation) :
Since
TNF also
induces leptin , a hormone secreted by adipocytes that modulates food intake and metabolism, we questioned the role of leptin in TNF induced pathology