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IFNB1 — TLR2

Text-mined interactions from Literome

Schilling et al., J Immunol 2002 : TLR4, but not TLR2 , agonists can induce IFN-beta expression via a mechanism that requires the adapter protein Toll-IL-1R domain containing adapter protein ( TIRAP ) /myeloid differentiation protein 88 ( MyD88 ) adapter-like ( Mal ), but not the adapter protein MyD88
Kaisho et al., Curr Mol Med 2003 : TLR2 can not induce IFN-alpha or IFN-beta , but TLR4 can lead to IFN-beta production ... Meanwhile, TLR3 , TLR7, and TLR9 can induce both IFN-alpha and IFN-beta
Aksoy et al., Eur J Immunol 2005 : In the same models of DC activation, PI3K inhibition increased DNA binding activity of NF-kappaB, but not interferon response factor (IRF)-3, the key transcription factors required for TLR mediated IFN-beta synthesis
Zhu et al., Blood 2007 : Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR independent production of IFN-beta
Koga et al., J Immunol 2006 (Chagas Disease) : TLR dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi ... These findings suggest that TLR dependent expression of IFN-beta is involved in resistance to T. cruzi infection through the induction of IRG47
Colonna et al., Eur J Immunol 2007 : These results demonstrate that TLR induce IFN-alpha or IFN-beta responses by activating distinct IRF, depending on the TLR ligand and the cell type
Rudd et al., Viral Immunol 2007 (Respiratory Syncytial Virus Infections) : The data demonstrate that production of IFN-beta , but not IFN-alpha, in RSV infected wild type DCs promotes chemokine production and toll-like receptor ( TLR ) expression, while limiting IL-12 production
Cross et al., J Immunol 2008 : CD45 regulates TLR induced proinflammatory cytokine and IFN-beta secretion in dendritic cells
Cao et al., Nat Immunol 2008 : Thus, mTOR signaling is crucial in TLR mediated IFN-alpha/beta responses by pDCs
Ciencewicki et al., J Interferon Cytokine Res 2009 : Interestingly, although influenza infection results in IFN-beta release both toward the apical and basolateral sides of the epithelium, TLR3 expression is only enhanced in cells stimulated with IFN-beta from the basolateral side
Chang et al., Virology 2009 : We further demonstrate that the HCMV derived interleukin 10 (IL-10) homolog functions similar to cellular IL-10 and broadly inhibits TLR induced transcriptional activation of IFN-alpha/beta genes in plasmacytoid dendritic cells ( PDCs ), a major type I IFN-producer in vivo that is highly resistant to HCMV infection in vitro
Yu et al., J Allergy Clin Immunol 2009 (Common Variable Immunodeficiency) : These TLR defects are restricted because CVID PBMCs stimulated with TLR ligands produced normal amounts of TNF-alpha, IL-6, and IL-12 ; TLR3 mediated expression of IFN-beta by CVID fibroblasts was normal
Renneson et al., Eur J Immunol 2009 : Neonatal myeloid DC were shown to be deficient in IFN-beta and IL-12 synthesis in response to TLR triggering
Kaiser et al., J Exp Med 2009 : Here, we investigated the role of the TPL-2 signaling pathway in TLR induction of interferon-beta (IFN-beta) and interleukin-10 (IL-10) in these cell types
Wang et al., J Clin Invest 2009 (Enterocolitis...) : In contrast, TLR3 activated expression of IFN-beta , a TRIF dependent response, was normal in Hfe KO macrophages and was unaffected by iron chelation
Burns et al., J Immunol 2010 (Bacteroidaceae Infections) : Proinflammatory cytokine production in response to P. gingivalis infection depends on TLR2, but it does not require MyD88 or TLR/IL-1R-domain containing adaptor inducing IFN-beta
Gabhann et al., J Immunol 2010 : SHIP-1-deficient macrophages display enhanced TLR induced IFN-beta production, and overexpression of SHIP-1 negatively regulates the ability of TLR3 and its adaptor, Toll/IL-1 receptor domain containing adaptor inducing IFN-beta, to induce IFN-beta promoter activity, indicating that SHIP-1 negatively regulates TLR induced IFN-beta production
Hartiala et al., J Immunol 2010 : The data show that 1 ) effective signaling via p38 MAPK ( and STAT1 and NF-kappaB ) is needed for CD38 expression and 2 ) TLR2 stimulation, as opposed to TLR4 stimulation, does not induce IFN-beta autocrine loop dependent expression of CD38 and secretion of IL-12
Simmons et al., J Immunol 2010 : Furthermore, M. tuberculosis and TLR2 agonists inhibited induction of IFN-alpha/beta and DC cross processing by CpG DNA
Cervantes et al., Proc Natl Acad Sci U S A 2011 : Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8 mediated induction of IFN-beta