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CSF2 — TLR2

Text-mined interactions from Literome

Flo et al., J Leukoc Biol 2001 : The level of TLR2 on monocytes was after 20 h up-regulated by LPS, GM-CSF , IL-1, and IL-10 and down-regulated by IL-4, IFN-gamma, and TNF ... On purified granulocytes, LPS, GM-CSF , and TNF down-regulated, and IL-10 modestly increased TLR2 expression after 2 h
Iwahashi et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : TLR-2 expression on monocytes was enhanced by macrophage colony stimulating factor ( M-CSF ) and interleukin-10 (IL-10), but was reduced by transforming growth factor beta1, while CD16 expression was inducible by these cytokines
Krutzik et al., Nat Med 2005 (Leprosy) : CD1b+ dendritic cells were expanded by TLR mediated upregulation of granulocyte-macrophage colony stimulating factor ( GM-CSF ) and its receptor, promoted T cell activation and secreted proinflammatory cytokines
O'Mahony et al., International journal of medical sciences 2008 : Of the cytokines examined, IFN-gamma and GM-CSF caused the greatest effects on TLR expression ... GM-CSF up-regulated expression of TLR2 and TLR4 in neutrophils and TLR2 in monocytes
Brosbøl-Ravnborg et al., Clin Exp Immunol 2009 (Crohn Disease) : In CD patients, TLR induced GM-CSF secretion was impaired by both NOD2 dependent and -independent mechanisms
Fukuzono et al., Arch Biochem Biophys 2010 : G-CSF and GM-CSF did not affect TLR agonist induced phosphorylation of ERK, p38, JNK, Akt, and IkappaBalpha ... These findings suggest that G-CSF and GM-CSF exert the opposite effects on TLR agonist induced cytokine production, and G-CSF negatively regulates TLR agonist induced cytokine production in neutrophils via activation of STAT3
Wilhelmsen et al., Innate Immun 2012 (Sepsis) : We found that TLR2 activation specifically induces the expression of the genes IL-6, IL-8, CSF2 , CSF3, ICAM1 and SELE by human umbilical vein ECs and human lung microvascular ECs