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STAT4 — TGFB1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database IL12 signaling mediated by STAT4:
STAT4 (dimer) complex (STAT4)
→
TGFB1 (TGFB1)
(transcription, activates)
Cai et al., J Immunol 2000*, Schindler et al., J Immunol 2001, Szabo et al., Science 2002, Morinobu et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., J Exp Med 1989*, Hunter et al., Eur J Immunol 1995*, Kaplan et al., Nature 1996
Evidence: mutant phenotype, assay, other species
Text-mined interactions from Literome
Sudarshan et al., J Immunol 1999
:
Furthermore, gel shift analysis showed that
TGF-beta1 did not
prevent activated
STAT4 and STAT5A from binding to DNA
Mathur et al., J Immunol 2007
:
We further show that
Stat4 is partially
required for the development of IL-23-, but not
TGFbeta1 plus IL-6 primed IL-17 secreting cells, and is absolutely required for IL-17 production in response to IL-23 plus IL-18