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SPP1 — TGFB1
Text-mined interactions from Literome
Himeno et al., J Bone Miner Res 2002
(Ossification, Heterotopic) :
In primary culture of Cbfa1-/- chondrocytes,
transforming growth factor (TGF) beta1 , platelet derived growth factor ( PDGF ), interleukin (IL)-1beta, and thyroid hormone ( T3 )
induced osteopontin and MMP-13 expression ... In primary culture of Cbfa1-/- chondrocytes,
transforming growth factor (TGF) beta1 , platelet derived growth factor ( PDGF ), interleukin (IL)-1beta, and thyroid hormone ( T3 )
induced osteopontin and MMP-13 expression
Khanna et al., Nephron. Experimental nephrology 2005
:
We also examined if CsA- and TAC induced
OPN expression is
dependent on
transforming growth factor ( TGF ) -beta expression
Serlin et al., J Cell Biochem 2006
:
Our results demonstrate a potent and dramatic increase in
osteopontin expression
induced by interleukin-1beta (IL-1beta), whereas tumor necrosis factor-alpha,
transforming growth factor-beta , and angiotensin II had minimal effect
Hsieh et al., Kidney Int 2006
(Diabetes Mellitus, Experimental...) :
High glucose, angiotensin II, phorbol 12-myristate 13-acetate and
transforming growth factor-beta 1 ( TGF-beta1 )
stimulated OPN mRNA expression in IRPTCs in a dose- and time dependent manner
Chen et al., Life Sci 2006
(Anoxia...) :
Combined with our previous finding that ANP signaling attenuates
transforming growth factor ( TGF ) -beta induced expression of
OPN and PN in isolated PASMCs, the current study supports the hypothesis that endogenous ANP plays an important anti-fibrogenic role in the pulmonary vascular adaptation to chronic hypoxia
Li et al., J Appl Physiol 2007
:
ANP and cGMP inhibited
TGF-beta1 induced pSmad2 and pSmad3 nuclear translocation and expression of periostin,
osteopontin , and plasminogen activator inhibitor-1 mRNA and protein, but not TGF-beta1 induced phosphorylation of Smad2 and Smad3
Partridge et al., Matrix Biol 2008
:
Subsequent molecular analyses established redox sensitivity of a 200 bp region within the 5 ' UTR of opn promoter and implicated nuclear factor kappa-B and
transforming growth factor beta inducible early gene 1 cis acting elements in the
regulation of
osteopontin
Biros et al., Int J Immunogenet 2009
(Aortic Aneurysm, Abdominal) :
This study suggests that polymorphism in TGFBR2 are associated with altered secretion of OPN, supporting a
role for
transforming growth factor beta in
OPN production
Georges et al., Int J Oncol 2010
(Adenocarcinoma...) :
Whereas
TGF-beta1 induced over-expression of
OPN and Runx2 in hepatocytes, it did not exert the same effect on hepatocytes co-cultured with CC531 cells, indicating that this response was abrogated by CC531 cells
Harris et al., J Bone Miner Res 1994
:
Effects of
transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin,
osteopontin , alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts
Staal et al., Endocrinology 1996
:
Antagonistic
effects of
transforming growth factor-beta on vitamin D3 enhancement of osteocalcin and
osteopontin transcription : reduced interactions of vitamin D receptor/retinoid X receptor complexes with vitamin E response elements
Malyankar et al., Kidney Int 1997
:
mRNA stability and nuclear run on assays suggest that
induction of
osteopontin expression by
TGF beta 1 and EGF is via increased transcription of the osteopontin gene