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RUNX3 — TGFB1

Text-mined interactions from Literome

Park et al., Eur J Immunol 2003 : Overexpression of Runx3 and Smad3/4 increased IgA secretion by both cell types in response to TGF-beta1
Brenner et al., Proc Natl Acad Sci U S A 2004 (Colitis...) : Runx3 plays a role during the development of sensory neurons and T cells and regulates transforming growth factor beta ( TGF-beta ) signaling in dendritic cells
Raveh et al., Dev Dyn 2005 : Runx3 functions during cell lineage decisions in thymopoiesis and neurogenesis and mediates transforming growth factor-beta signaling in dendritic cells
Ito et al., Cancer Res 2005 (Stomach Neoplasms) : Evidence is presented suggesting that transforming growth factor-beta is an inducer of nuclear translocation of RUNX3 , and RUNX3 in the cytoplasm of cancer cells is inactive as a tumor suppressor
Hasegawa et al., Cancer Sci 2007 (Biliary Tract Neoplasms) : To elucidate the role of RUNX3 in transforming growth factor ( TGF ) -beta signaling in biliary tract cancer, we transfected Mz-ChA-2 cells, which do not express RUNX3 but have intact TGF-beta type II receptor and SMAD4 genes, with the RUNX3 expression plasmid pcDNA3.1/RUNX3 or with the vector pcDNA3.1 as a control
Seo et al., Eur J Immunol 2009 : We have shown that Smad3/4, Runx3 , and p300 mediate TGF-beta1 induced germ-line ( GL ) gamma2b transcription and that there is a potential Smad binding element ( SBE, CAGAC, -38/-34 ) and Runx binding element ( TGTGGGT, +41/+47 ) in the promoter region
Klunker et al., J Exp Med 2009 : In this study, we show that the transforming growth factor-beta ( TGF-beta ) induces the expression of the Runt related transcription factors RUNX1 and RUNX3 in CD4 ( + ) T cells
Lee et al., Cell Tissue Res 2010 (Lung Injury...) : Our results indicate that pERK, Tgf-beta1 , CCSP, pJnk, and HSP70 are dramatically down-regulated by loss of Runx3 during lung wound healing
Shi et al., J Immunol 1998 (Lymphoma, B-Cell) : CBF alpha3 ( AML2 ) is induced by TGF-beta1 to bind and activate the mouse germline Ig alpha promoter ... Although all three CBF alpha family members activate the GL alpha promoter, only CBF alpha3 ( AML-2 ) is induced by TGF-beta1 in splenic B and I.29mu cells ... Together the data indicate that TGF-beta1 induction of the alpha promoter involves induction of CBF alpha3 , which binds to the TbetaRE of the promoter along with one or more proteins