Gene interactions and pathways from curated databases and text-mining

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DCN — TGFB1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Asakura et al., Hum Pathol 1999 (Adenocarcinoma...) : Our results suggest that TGF-beta1 has an important role in the formation of central fibrosis in pulmonary adenocarcinoma, and decorin may play a role as a negative feedback regulator in the production of TGF-beta1 in pulmonary adenocarcinoma
Brown et al., J Biol Chem 1999 : Decorin synthesis was reduced by either TGF-beta1 or serum
Mogyorósi et al., Nephrol Dial Transplant 1999 (Diabetic Nephropathies) : We review evidence that a surfeit rather than a deficit in decorin expression exists in diabetic renal disease, and that there exists a negative feed-back loop whereby TGF-beta1 induces down-regulation of decorin expression
Takagi et al., Histochem J 1999 : Effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on gene expression of decorin and biglycan by cultured osteoblastic cells ... Both rhBMP-2 and TGF-beta1 inhibit decorin mRNA expression in osteoblasts at varying stages of differentiation, but their effects on biglycan mRNA expression and alkaline phosphatase are different
Yamada et al., Histochem J 1999 : Effects of transforming growth factor-beta1 on the gene expression of decorin , biglycan, and alkaline phosphatase in osteoblast precursor cells and more differentiated osteoblast cells
Bodo et al., J Dent Res 1999 (Cleft Lip...) : In fact, in CLP fibroblasts, TGFalpha and TGFbeta1 down-regulated PG decorin transcript, TGFbeta1 increased collagen and GAG in both cellular and extracellular compartments, and TGFbeta3 promoted secretory processes of cells
Wu et al., J Dermatol Sci 2001 (Chronic Disease...) : On the other hand, TGF-beta1 resulted in 40 % reductions of decorin expression in both control and patient fibroblasts
Abdel-Wahab et al., Biochem J 2002 : Decorin suppresses transforming growth factor-beta induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+ dependent phosphorylation of Smad2 at serine-240
De Cosmo et al., Nephron 2002 (Diabetes Mellitus, Type 1...) : Decorin , a proteoglycan which is a component of the extracellular matrix, regulates TGF-beta1 activity and expression
Swirski et al., Eur J Immunol 2004 (Eosinophilia) : Concomitant airway expression of granulocyte-macrophage colony stimulating factor and decorin , a natural inhibitor of transforming growth factor-beta , breaks established inhalation tolerance
Köninger et al., Biochem Biophys Res Commun 2004 (Adenocarcinoma...) : Interestingly, TGFbeta1 and conditioned medium derived from pancreatic cancer cell lines synergistically suppressed the expression of known anti-tumor factors decorin and lumican, but stimulated the expression of pro-metastatic factor versican in cultured PSCs
Fu et al., Clin Orthop Relat Res 2005 : Transforming growth factor-beta1 increased the messenger ribonucleic acid level of procollagen Type I in Type I collagen coated plates, but it suppressed the messenger ribonucleic acid level of decorin in fibronectin coated plates
Li et al., Poult Sci 2006 (Muscle Weakness...) : Effect of transforming growth factor-beta on decorin and beta1 integrin expression during muscle development in chickens
Allen et al., Orthod Craniofac Res 2006 : In monolayer, TGF-beta3 and TGF-beta1 increased decorin and biglycan gene expression relative to passaged controls
Jahanyar et al., J Heart Lung Transplant 2007 (Endomyocardial Fibrosis...) : Decorin mediated transforming growth factor-beta inhibition ameliorates adverse cardiac remodeling
Li et al., Mol Ther 2007 (Fibrosis) : We have shown that decorin , a small leucine-rich proteoglycan, can inhibit transforming growth factor (TGF)-beta1 to prevent fibrous scar formation and improve muscle healing after injury
Wu et al., Eur J Med Res 2007 : Decorin gene transfer inhibited the expression of TGFbeta1 and ECM in rat mesangial cells
Li et al., Poult Sci 2009 : Effect of transforming growth factor-beta1 on decorin expression and muscle morphology during chicken embryonic and posthatch growth and development ... The expression of decorin can be regulated by TGF-beta1 during muscle proliferation and differentiation ... The present study investigated the effect of TGF-beta1 on decorin expression and intracellular connective tissue development during skeletal muscle growth ... Transforming growth factor-beta1 reduced decorin in both the endomysium and perimysium from 17 ED to 6 wk posthatch ... The results from the current study suggest that the effect of TGF-beta1 on decorin expression and localization was likely associated with altered development of the perimysium and the regulation of muscle fiber development
Gogly et al., J Mol Cell Cardiol 2009 : Interestingly, in contrast with other MMPs ( which were not influenced at a transcription level ), GF stimulated the release of TGF-beta1, which in turn inhibited the transcription and synthesis of MMP-7, as shown by neutralizing MMP-7 inhibition due to gingival fibroblast by overexpressing decorin ( a TGF beta 1 inhibitor ) or by silencing TGF beta 1 using siRNA
Zheng et al., Endocr Res 2010 (Diabetes Mellitus, Experimental) : Exogenous decorin effectively suppressed the increased activities of TGF-beta1/Smads signaling and partly attenuated collagen deposits in the alveolar septum
Wang et al., Zhonghua Er Ke Za Zhi 2010 : To investigate the mechanisms of decorin inhibiting epithelial-to-mesenchymal transition ( EMT ) induced by transforming growth factor beta1 ( TGF-beta1 ) in renal tubular epithelial cells
Zhang et al., Nephron. Experimental nephrology 2010 (Diabetes Mellitus, Experimental...) : Decorin , a natural inhibitor of TGF-beta(1) , may have healing properties
Yamaguchi et al., Nature 1990 : As transforming growth factor-beta induces synthesis of decorin in many cell types, our results suggest that decorin may be a component of a feedback system regulating cell growth
Merrilees et al., J Vasc Res 1993 : Both the distribution of TGF-beta 1 and its known differential effects on versican and decorin synthesis suggest that it may play a significant role in the formation and maintenance of the PGL
Kähäri et al., J Invest Dermatol 1995 : Retinoic acid did not alter the effect of transforming growth factor-beta on decorin or biglycan production or mRNA levels
Mauviel et al., J Biol Chem 1995 : Furthermore, transforming growth factor-beta ( TGF-beta ) down-regulated decorin gene expression in an additive manner with TNF-alpha
Takeuchi et al., J Cell Physiol 1995 : The major proteoglycans synthesized by these cells were decorin and biglycan, and TGF-beta 1 markedly stimulated the synthesis of decorin in MC3T3-E1 and of biglycan in MG 63 cells
Teicher et al., In Vivo 1997 : Administration of decorin , a naturally occurring inhibitor of TGF-beta 1 , to animals bearing the EMT-6/PRK5 beta 1E tumor prior to treatment of the animals with the antitumor alkylating agents restored drug sensitivity to the tumor and to the bone marrow CFU-GM. Administration of decorin prior to the antitumor alkylating agents produced very little or no increase in the response of the EMT6/Parent tumor or the bone marrow CFU-GM from those animals
Ständer et al., Gene Ther 1998 (Glioma) : Here, we report that ectopic expression of the small TGF-beta binding proteoglycan, decorin , inhibits not only TGF-beta bioactivity but also TGF-beta 1 and TGF-beta 2 mRNA transcription and TGF-beta protein synthesis by human LN-18, LN-229, T98G and rat C6 glioma cells in vitro