Ruscher et al., J Neurosci 2002
(Hypoxia-Ischemia, Brain) :
In astrocytes the OGD enhanced the nuclear translocation of hypoxia-inducible factor 1 (HIF-1), the major transcription factor regulating EPO expression
Piuhola et al., Clin Sci (Lond) 2008
(Myocardial Ischemia...) :
BNP ( B-type natriuretic peptide ) secretion ( 28+/-8 % ; P < 0.05 ) and nuclear transcription factor GATA-4 DNA binding activity ( 51 % ; P < 0.05 ) were both significantly increased by EPO and blocked by bosentan