Thangaraju et al., J Biol Chem 1999
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Overexpression of the anti-apoptotic protein Bcl-2 in MCF-7 cells inhibited SST induced apoptosis upstream of acidification by inhibiting p53 dependent induction of Bax as well as by raising the resting pH(i) and attenuating SST induced decrease in pH(i) Wolfe et al., Mol Cell Endocrinol 1992
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The present studies were directed to determine whether peptide histidine isoleucine (PHI) affects expression of the gastrin and somatostatin genes and whether such effects may be functionally linked ... PHI also decreased carbachol stimulated antral gastrin release and simultaneously increased somatostatin release
Szecówka et al., Am J Physiol 1983
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PHI increased the release of insulin, glucagon, and somatostatin ... When arginine was used as a secretagogue, PHI ( 10 nmol/liter ) potentiated secretion of insulin, glucagon, and somatostatin