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ICAM1 — SPP1

Text-mined interactions from Literome

Mangan et al., Cardiovasc Res 2007 : OPG but not OPN stimulated a dose dependent increase in the expression of intercellular adhesion molecule-1 , vascular cell adhesion molecule-1 and E-selectin by endothelial cells in the presence of TNF-alpha ( p < or=0.05 ) which was reflected by enhanced binding of THP-1 monocytes
Ahmed et al., Molecular cancer 2010 (Breast Neoplasms) : In this study, we report that purified native OPN induces ICAM-1 expression in breast cancer cells ... The data revealed that OPN induces NF-kappaB activation and NF-kappaB dependent ICAM-1 expression ... We also delineated the role of mTOR and p70S6 kinase in OPN induced ICAM-1 expression ... The study suggests that inhibition of mTOR by rapamycin augments whereas overexpression of mTOR/p70S6 kinase inhibits OPN induced ICAM-1 expression ... These results suggest that blocking of OPN induced ICAM-1 expression through mTOR/p70S6 kinase signaling pathway may be an important therapeutic strategy for the treatment of breast cancer