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SNAP25 — STX8
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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Gene Ontology Complexes SNARE complex:
SNARE complex complex (STX1A-SNX4-VAMP8-STX16-NPEPL1-BET1L-DOC2B-SNAP25-YKT6-CPLX2-GOSR2-CPLX1-BNIP1-STX8-VAMP3-VAMP5-VAMP4-VAMP7-SYT1-STX3-STX7-STX6-STX11-STX12-VTI1A-STX16-STX19)
Fernández-Chacón et al., Annu Rev Physiol 1999, Polgár et al., Blood 2002, Tian et al., J Biol Chem 2003, Pryor et al., EMBO Rep 2004, Tai et al., Mol Biol Cell 2004, Sudhof et al., Annu Rev Neurosci 2004, Nakajima et al., EMBO J 2004, Sander et al., Eur J Immunol 2008, Ghiani et al., Mol Psychiatry 2010, Pérez-Victoria et al., Mol Cell Biol 2009, Itakura et al., Cell 2012, Pirooz et al., Proc Natl Acad Sci U S A 2014
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STRING interaction:
STX8
—
SNAP25
(interaction, mapped from grid kegg_pathways mint intact)
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STRING interaction:
SNAP25
—
STX8
(interaction, mapped from grid kegg_pathways mint intact)
Text-mined interactions from Literome
Hepp et al., Glia 1999
:
Although
syntaxin , synaptobrevin, and cellubrevin have been shown to be expressed by cultured astrocytes,
SNAP-25 has not been
detected
Tsujimoto et al., J Biol Chem 2000
:
The presence of
syntaxin enhances the binding of Hrs-2 to
SNAP-25
Vogel et al., J Biol Chem 2000
:
Furthermore, the association of
SNAP-25 with membranes is dramatically
enhanced by
syntaxin , and the transmembrane domain of syntaxin is essential for this effect ... Surprisingly, despite the importance of the SNAP-25 palmitoylation domain for membrane anchoring at steady state, removal of this domain did not inhibit the initial association of newly synthesized
SNAP-25 with membranes in the
presence of
syntaxin
Yang et al., J Gen Physiol 2007
(Calcium Signaling) :
Phosphomimetic mutation of Ser-187 of
SNAP-25 increases both
syntaxin binding and highly Ca2+-sensitive exocytosis
O'Connor et al., Proc Natl Acad Sci U S A 1997
:
These data support the notion that
syntaxin mediated
SNARE complexes are necessary for docked synaptic vesicles to fuse