Facchiano et al., J Cell Sci 2000
:
These in vitro studies show that bFGF significantly inhibits PDGF-BB induced SMC migration and proliferation and that this effect is mediated by both PDGF-Ralpha and bFGF receptor
Watson et al., Endocrinology 2002
(Diabetes Mellitus, Experimental...) :
Thus, both in vitro and in vivo loss of CREB content and activity and subsequent accumulation of PDGFRalpha may contribute to SMC activation during diabetes