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SMAD4 — SMURF2

Pathways - manually collected, often from reviews:

• Reactome Reaction: SMAD4 → SMURF2 (reaction) Tang et al., EMBO J 2011
• Reactome Reaction: SMAD4 → SMURF2 (indirect_complex) Tang et al., EMBO J 2011

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 48 proteins (physical association, tandem affinity purification) Brown et al., J Cell Biochem 2008
• IRef Intact Interaction: Complex of 43 proteins (physical association, tandem affinity purification) Brown et al., J Cell Biochem 2008
• MIPS Negatome - no physical interaction between proteins Interaction: SMAD4 — SMURF2 (Absence of interaction, coimmunoprecipitation) Bonni et al., Nat Cell Biol 2001

Text-mined interactions from Literome

Lin et al., J Biol Chem 2000 : Ectopic expression of Smurf2 was sufficient to reduce the steady-state levels of Smad1 and Smad2 but not Smad3 or Smad4
Ohashi et al., FEBS Lett 2005 : TGF-beta mediated Smurf2 promoter activation was inhibited by Smad7 or an activin receptor-like kinase 5 inhibitor but not by dominant negative Smad or disruption of Smad binding elements in the promoter
Tan et al., American journal of physiology. Renal physiology 2008 (Chronic Disease...) : Ectopic expression of Smurf2 was sufficient to reduce the steady-state levels of Smad2, but not Smad1, Smad3, Smad4 , and Smad7, in HKC-8 cells
Zhang et al., Burns Incl Therm Inj 2012 (Burns...) : Smad proteins are important intracellular mediators of TGF-ß1 signaling, and Smad ubiquitination regulatory factor 2 ( Smurf2 ), an ubiquitin ligase for Smads, plays critical roles in the regulation of TGF-ß1/Smad signaling