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NODAL — SMAD4

Text-mined interactions from Literome

Esguerra et al., Development 2007 : Thus, although the role of Smad proteins in mediating Nodal signaling is well documented, the functional characterization of Ttrap provides insight into a novel Smad partner that plays an essential role in the fine tuning of this signal transduction cascade
D'Andrea et al., J Cell Biol 2008 : In cripto ( F78A/F78A ) mouse embryos, Nodal fails to expand its own expression domain and that of cripto, indicating that F78 is essential in vivo to stimulate Smad dependent Nodal autoinduction
Xi et al., Cell 2011 : Nodal receptors induce the formation of companion Smad4-Smad2/3 and TRIM33-Smad2/3 complexes
De Silva et al., Frontiers in endocrinology 2012 : To determine which receptor and Smad mediate the growth promoting effect of Nodal , we transfected siRNAs targeting ALK4, ALK7, Smad2, or Smad3 into Nodal overexpressing cells and observed that cell growth was significantly inhibited by ALK4, ALK7, and Smad3 siRNAs