UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to SMAD3

SMAD3 — SMURF1

Pathways - manually collected, often from reviews:

NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2) (modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database TGF-beta receptor signaling: SMAD7/SMURF1-2 complex (SMAD7-SMURF1_SMURF2) → PML/SARA/SMAD2-3 complex (ZFYVE9-SMAD2_SMAD3-PML) (modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1/PML/SARA/SMAD2-3/AP2B2 complex (TGFBR1-PML-ZFYVE9-SMAD2_SMAD3-TGFBR2) → TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) (modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species
NCI Pathway Database TGF-beta receptor signaling: TGFB/TGFBR2/TGFBR1/SMAD7/SMURF1-2/CAV1 complex (TGFBR1-SMAD7-SMURF1_SMURF2-CAV1-TGFBR2) → PML/SARA/SMAD2-3 complex (ZFYVE9-SMAD2_SMAD3-PML) (modification, collaborate)
Wu et al., Science 2000, Yao et al., J Biol Chem 2000, Kavsak et al., Mol Cell 2000, Ebisawa et al., J Biol Chem 2001, Huse et al., Mol Cell 2001, Lu et al., J Biol Chem 2002, Suzuki et al., J Biol Chem 2002, Hayes et al., J Cell Biol 2002, Yao et al., Mol Biol Cell 2002, Di Guglielmo et al., Nat Cell Biol 2003, Lin et al., Nature 2004, Hayashi et al., Cell 1997, Nakao et al., Nature 1997, Abdollah et al., J Biol Chem 1997, Lo et al., EMBO J 1998, Chen et al., Genes Dev 1998, Tsukazaki et al., Cell 1998
Evidence: mutant phenotype, assay, physical interaction, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Bind Interaction: SMAD3 — SMURF1 Colland et al., Genome Res 2004
IRef Bind_translation Interaction: SMAD3 — SMURF1 (two hybrid) Colland et al., Genome Res 2004
IRef Bind_translation Interaction: SMAD3 — SMURF1 (coimmunoprecipitation) Barrios-Rodiles et al., Science 2005
IRef Biogrid Interaction: SMAD3 — SMURF1 (physical association, affinity chromatography technology) Gao et al., Mol Cell 2009
IRef Biogrid Interaction: SMAD3 — SMURF1 (direct interaction, two hybrid) Colland et al., Genome Res 2004
IRef Biogrid Interaction: SMAD3 — SMURF1 (physical association, affinity chromatography technology) Komuro et al., Oncogene 2004
IRef Hprd Interaction: SMURF1 — SMAD3 (in vivo) Barrios-Rodiles et al., Science 2005
IRef Intact Interaction: SMAD3 — SMURF1 (physical association, two hybrid) Colland et al., Genome Res 2004
IRef Ophid Interaction: SMAD3 — SMURF1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Shi et al., Am J Physiol Lung Cell Mol Physiol 2004 (Lung Neoplasms) : Further studies found that overexpression of Smurf1 reduced BMP-specific Smad1 and Smad5, but not Smad8 , protein levels
Nam et al., Exp Mol Med 2010 : Finally, Smad7 and Smurf1 negatively regulated the TGF-beta1 induced and Smad3/4 mediated VEGF expression