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NPPA — SMAD3
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Li et al., J Appl Physiol 2007
:
ANP signaling
inhibits TGF-beta induced Smad2 and
Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells ...
ANP and cGMP
inhibited TGF-beta1 induced pSmad2 and pSmad3 nuclear translocation and expression of periostin, osteopontin, and plasminogen activator inhibitor-1 mRNA and protein, but not TGF-beta1 induced phosphorylation of Smad2 and
Smad3
Lo et al., J Cell Biochem 2008
:
The present study was performed to explore the
effect of
ANP on high glucose activated transforming growth factor-beta1 ( TGF-beta1 ),
Smad and collagen synthesis in renal proximal epithelial cells