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ECM1 — SMAD3
Text-mined interactions from Literome
Zhao et al., Biochem Biophys Res Commun 2006
:
We hypothesized that PPARgamma agonists inhibit transforming growth factor (TGF)beta1-activation of TGFbeta receptor ( TGFbetaR ) -1 signaling in quiescent stellate cells, thereby abrogating
Smad3 dependent
induction of
extracellular matrix ( ECM ) genes, such as PAI-1 and collagen-1alphaI
Zode et al., Glia 2009
(Glaucoma) :
Gremlin stimulation of
ECM required activation of TGF-beta receptor and
R-Smad3 ... Gremlin stimulation of
ECM required activation of TGF-beta receptor and
R-Smad3
Pines et al., Histol Histopathol 2011
(Fibrosis...) :
Halofuginone, an inhibitor of
Smad3 phosphorylation downstream of TGFß signaling,
inhibits the activation of fibroblasts and their ability to synthesize
ECM , regardless of their origin or location
Guo et al., Am J Physiol Cell Physiol 2011
:
In addition to a-SMA, RGC-32 and
Smad3 also synergistically
activate the expression of
extracellular matrix protein fibronectin and downregulate the epithelial marker E-cadherin
Zode et al., Molecular vision 2011
(Glaucoma) :
Furthermore, inhibition of TGF-ß I receptor activity by SB431542 or inhibition of
Smad3 phosphorylation by SIS3
blocked TGF-ß2 stimulated
ECM expression as well as activation of downstream canonical pathway signaling molecules