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PSPN — RET

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Lindahl et al., J Biol Chem 2001*, Enokido et al., Curr Biol 1998*
• IRef Ophid Interaction: RET — PSPN (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: RET — PSPN (aggregation, confirmational text mining) Lindahl et al., J Biol Chem 2001*

Text-mined interactions from Literome

Yang et al., FEBS Lett 2004 : Here, we show that the mouse GFRalpha4 is a functional, N-glycosylated, glycosylphosphatidylinositol (GPI) anchored protein, which mediates persephin (PSPN) induced phosphorylation of RET , but has an almost undetectable capacity to recruit RET into the 0.1 % Triton X-100 insoluble membrane fraction
Enokido et al., Curr Biol 1998 : These results demonstrate that GFR alpha-4 is the ligand binding subunit for persephin and that persephin , like GDNF and neurturin, also requires Ret for signalling