◀ Back to RET

GFRA1 — RET

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RET → Complex of GFRA1-RET (directlyIncreases, GFRA1/RET Activity)
  Evidence: The GPI anchor localizes GFR-a to lipid rafts. GDNF binding to GFR-a recruits RET to lipid rafts, thereby facilitating RET interaction with the c-Src kinase and the FRS2 docking protein.
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/Dok4 complex (RET-DOK4-GFRA1-GDNF) → RAP1A/GTP complex (RAP1A) (modification, activates) Uchida et al., J Cell Sci 2006
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/Dok4 complex (RET-DOK4-GFRA1-GDNF) → RAP1A/GDP complex (RAP1A) (modification, activates) Uchida et al., J Cell Sci 2006
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → Dok6 (DOK6) (modification, collaborate) Crowder et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → Src (SRC) (modification, collaborate) Crowder et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/Dok6 complex (RET-DOK6-GFRA1-GDNF) (modification, collaborate)
  Crowder et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Dok6 (DOK6) → RET51/GFRalpha1/GDNF/Dok6 complex (RET-DOK6-GFRA1-GDNF) (modification, collaborate)
  Crowder et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Src (SRC) → RET51/GFRalpha1/GDNF/Dok6 complex (RET-DOK6-GFRA1-GDNF) (modification, activates)
  Crowder et al., J Biol Chem 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RhoA (RHOA) (modification, activates) Murakami et al., Oncogene 1999, Panta et al., Surgery 2004*, Panta et al., Surgery 2005
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → FAK (PTK2) (modification, activates) Murakami et al., Oncogene 1999, Panta et al., Surgery 2004*, Panta et al., Surgery 2005
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → IRS1 (IRS1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → IRS1 (IRS1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: IRS1 (IRS1) → RET9/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → IRS1 (IRS1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) (modification, collaborate)
  Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → IRS1 (IRS1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) → IRS1 (IRS1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) → SHC (SHC1) (modification, collaborate) Hennige et al., Mol Cell Endocrinol 2000, Melillo et al., Oncogene 2001, Lorenzo et al., Oncogene 1997, Arighi et al., Oncogene 1997
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) (modification, activates)
  Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) → HRAS/GTP complex (HRAS) (modification, activates) Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) → HRAS/GDP complex (HRAS) (modification, activates) Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) → HRAS/GTP complex (HRAS) (modification, inhibits) Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) → HRAS/GDP complex (HRAS) (modification, inhibits) Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → Shank3 (SHANK3) (modification, collaborate) Schuetz et al., J Cell Biol 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/Shank3 complex (RET-SHANK3-GFRA1-GDNF) (modification, collaborate)
  Schuetz et al., J Cell Biol 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Shank3 (SHANK3) → RET9/GFRalpha1/GDNF/Shank3 complex (RET-SHANK3-GFRA1-GDNF) (modification, collaborate)
  Schuetz et al., J Cell Biol 2004
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SOS1 (SOS1) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SOS1 (SOS1) → RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: IRS2 (IRS2) → RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, activates)
  Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) → JNK1 (MAPK8) (modification, activates) Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/Enigma complex (RET-PDLIM7-GFRA1-GDNF) → RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Borrello et al., Biochem Biophys Res Commun 2002*, Durick et al., J Biol Chem 1996*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/Enigma complex (RET-PDLIM7-GFRA1-GDNF) → Enigma (PDLIM7) (modification, collaborate) Borrello et al., Biochem Biophys Res Commun 2002*, Durick et al., J Biol Chem 1996*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → Enigma (PDLIM7) (modification, collaborate) Borrello et al., Biochem Biophys Res Commun 2002*, Durick et al., J Biol Chem 1996*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → IRS2 (IRS2) (modification, activates) Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Hennige et al., Mol Cell Endocrinol 2000, Hayashi et al., Oncogene 2000, Maeda et al., Biochem Biophys Res Commun 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/Shank3/Grb2 complex (RET-SHANK3-GRB2-GFRA1-GDNF) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Schuetz et al., J Cell Biol 2004
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SHP2 (PTPN11) → RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SHP2 (PTPN11) → RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → GRB2 (GRB2) (modification, collaborate) Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → SOS1 (SOS1) (modification, collaborate) Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SOS1 (SOS1) → RET9/GFRalpha1/GDNF/SHC/Grb2/SOS1 complex (RET-GFRA1-GDNF-SOS1-SHC1-GRB2) (modification, collaborate)
  Hayashi et al., Oncogene 2000, van Weering et al., Oncogene 1995
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/PKC alpha complex (RET-PRKCA-GFRA1-GDNF) (modification, collaborate)
  Andreozzi et al., Oncogene 2003*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → PKC alpha (PRKCA) (modification, collaborate) Andreozzi et al., Oncogene 2003*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/PKC alpha complex (RET-PRKCA-GFRA1-GDNF) → PKC alpha (PRKCA) (modification, collaborate) Andreozzi et al., Oncogene 2003*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Fukuda et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RasGAP (RASA1) → RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) (modification, collaborate)
  Murakami et al., Biochem Biophys Res Commun 1999, Grimm et al., J Cell Biol 2001, Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RasGAP (RASA1) → RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) (modification, collaborate)
  Murakami et al., Biochem Biophys Res Commun 1999, Grimm et al., J Cell Biol 2001, Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) (modification, collaborate)
  Murakami et al., Biochem Biophys Res Commun 1999, Grimm et al., J Cell Biol 2001, Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) → NCK1 (NCK1) (modification, collaborate) Murakami et al., Biochem Biophys Res Commun 1999, Grimm et al., J Cell Biol 2001, Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK/RasGAP/NCK complex (RET-GFRA1-GDNF-DOK1-NCK1-RASA1) → NCK1 (NCK1) (modification, collaborate) Murakami et al., Biochem Biophys Res Commun 1999, Grimm et al., J Cell Biol 2001, Murakami et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/IRS1 complex (RET-IRS1-GFRA1-GDNF) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Melillo et al., Oncogene 2001
  Evidence: mutant phenotype, assay
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/Shank3 complex (RET-SHANK3-GFRA1-GDNF) (modification, collaborate)
  Schuetz et al., J Cell Biol 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/Shank3/Grb2 complex (RET-SHANK3-GRB2-GFRA1-GDNF) (modification, collaborate)
  Schuetz et al., J Cell Biol 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/Shank3 complex (RET-SHANK3-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/Shank3/Grb2 complex (RET-SHANK3-GRB2-GFRA1-GDNF) (modification, collaborate)
  Schuetz et al., J Cell Biol 2004
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: FRS2 (FRS2) → RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Melillo et al., Mol Cell Biol 2001*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: FRS2 (FRS2) → RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Melillo et al., Mol Cell Biol 2001*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Melillo et al., Mol Cell Biol 2001*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GFRalpha1/GDNF complex (GFRA1-GDNF) → RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Carter et al., Cytogenet Cell Genet 2001*, Tahira et al., Oncogene 1990*, Myers et al., Oncogene 1995*
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GFRalpha1/GDNF complex (GFRA1-GDNF) → RET51 (RET) (modification, collaborate) Carter et al., Cytogenet Cell Genet 2001*, Tahira et al., Oncogene 1990*, Myers et al., Oncogene 1995*
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET51 (RET) (modification, collaborate) Carter et al., Cytogenet Cell Genet 2001*, Tahira et al., Oncogene 1990*, Myers et al., Oncogene 1995*
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → Dok4 (DOK4) (modification, collaborate) Grimm et al., J Cell Biol 2001, Uchida et al., J Cell Sci 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/Dok4 complex (RET-DOK4-GFRA1-GDNF) (modification, collaborate)
  Grimm et al., J Cell Biol 2001, Uchida et al., J Cell Sci 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Dok4 (DOK4) → RET51/GFRalpha1/GDNF/Dok4 complex (RET-DOK4-GFRA1-GDNF) (modification, collaborate)
  Grimm et al., J Cell Biol 2001, Uchida et al., J Cell Sci 2006
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) → RET/GFRalpha1/GDNF complex (GDNF-RET-GFRA1) (modification, collaborate)
  Gujral et al., Cancer Res 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Murakami et al., Oncogene 1999
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → Crk/p130 Cas/Paxillin complex (CRK-BCAR1-PXN) (modification, activates)
  Murakami et al., Oncogene 1999
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GFRalpha1/GDNF complex (GFRA1-GDNF) → RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Wong et al., Mol Cell Biol 2005*, Jing et al., Cell 1996*
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GFRalpha1/GDNF complex (GFRA1-GDNF) → RET9 (RET) (modification, collaborate) Wong et al., Mol Cell Biol 2005*, Jing et al., Cell 1996*
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET9 (RET) (modification, collaborate) Wong et al., Mol Cell Biol 2005*, Jing et al., Cell 1996*
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → Gab1 (GAB1) (modification, collaborate) Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → GRB2 (GRB2) (modification, collaborate) Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Gab1 (GAB1) → RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET9/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Gab1 (GAB1) → RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Gab1 (GAB1) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/SHC/GAB1/Grb2 complex (RET-GFRA1-GDNF-SHC1-GRB2-GAB1) → RET51/GFRalpha1/GDNF/SHC complex (RET-SHC1-GFRA1-GDNF) (modification, collaborate)
  Hayashi et al., Oncogene 2000
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Dok5 (DOK5) → RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Grimm et al., J Cell Biol 2001
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: Dok5 (DOK5) → RET51/GFRalpha1/GDNF/Dok5 complex (RET-DOK5-GFRA1-GDNF) (modification, collaborate)
  Grimm et al., J Cell Biol 2001
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/Dok5 complex (RET-DOK5-GFRA1-GDNF) (modification, collaborate)
  Grimm et al., J Cell Biol 2001
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: FRS2 (FRS2) → RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Melillo et al., Mol Cell Biol 2001*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: FRS2 (FRS2) → RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Melillo et al., Mol Cell Biol 2001*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET9/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET9/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Melillo et al., Mol Cell Biol 2001*
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB2 (GRB2) → RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) → SHP2 (PTPN11) (modification, collaborate) Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/FRS2 complex (RET-FRS2-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: SHP2 (PTPN11) → RET51/GFRalpha1/GDNF/FRS2/SHP2/Grb2 complex (RET-FRS2-PTPN11-GRB2-GFRA1-GDNF) (modification, collaborate)
  Kurokawa et al., Oncogene 2001, Hadari et al., Mol Cell Biol 1998
  Evidence: assay, physical interaction, other species
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/GRB10 complex (RET-GRB10-GFRA1-GDNF) → RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) (modification, collaborate)
  Pandey et al., J Biol Chem 1995, Pandey et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/GRB10 complex (RET-GRB10-GFRA1-GDNF) → GRB7 (GRB7) (modification, collaborate) Pandey et al., J Biol Chem 1995, Pandey et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/GRB10 complex (RET-GRB10-GFRA1-GDNF) → GRB10 (GRB10) (modification, collaborate) Pandey et al., J Biol Chem 1995, Pandey et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/GRB10 complex (RET-GRB10-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/Grb7 complex (RET-GRB7-GFRA1-GDNF) (modification, collaborate)
  Pandey et al., J Biol Chem 1995, Pandey et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → GRB7 (GRB7) (modification, collaborate) Pandey et al., J Biol Chem 1995, Pandey et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → GRB10 (GRB10) (modification, collaborate) Pandey et al., J Biol Chem 1995, Pandey et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/Grb7 complex (RET-GRB7-GFRA1-GDNF) (modification, collaborate)
  Pandey et al., J Biol Chem 1995, Pandey et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB7 (GRB7) → RET51/GFRalpha1/GDNF/Grb7 complex (RET-GRB7-GFRA1-GDNF) (modification, collaborate)
  Pandey et al., J Biol Chem 1995, Pandey et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: GRB10 (GRB10) → RET51/GFRalpha1/GDNF/Grb7 complex (RET-GRB7-GFRA1-GDNF) (modification, collaborate)
  Pandey et al., J Biol Chem 1995, Pandey et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) (modification, collaborate)
  Murakami et al., Biochem Biophys Res Commun 1999, Murakami et al., J Biol Chem 2002, Shi et al., J Biol Chem 2004*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF complex (RET-GFRA1-GDNF) → p62DOK (DOK1) (modification, collaborate) Murakami et al., Biochem Biophys Res Commun 1999, Murakami et al., J Biol Chem 2002, Shi et al., J Biol Chem 2004*
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events regulated by Ret tyrosine kinase: RET51/GFRalpha1/GDNF/DOK1 complex (RET-DOK1-GFRA1-GDNF) → p62DOK (DOK1) (modification, collaborate) Murakami et al., Biochem Biophys Res Commun 1999, Murakami et al., J Biol Chem 2002, Shi et al., J Biol Chem 2004*
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GFRA1 — RET (direct interaction, pull down) Cik et al., J Biol Chem 2000*
• IRef Biogrid Interaction: GFRA1 — RET (direct interaction, pull down) Klein et al., Nature 1997*
• IRef Dip Interaction: GFRA1 — RET (physical association, enzyme linked immunosorbent assay) Kjaer et al., Nature structural & molecular biology 2010*
• IRef Hprd Interaction: GFRA1 — RET (in vivo) Tansey et al., Neuron 2000*
• IRef Ophid Interaction: GFRA1 — RET (aggregation, confirmational text mining) Cik et al., J Biol Chem 2000*
• IRef Ophid Interaction: GFRA1 — RET (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Eketjäll et al., EMBO J 1999 : Although impaired in binding GFRalpha1 efficiently, these mutants still required GFRalpha1 for c-Ret activation
Charlet-Berguerand et al., Cell Signal 2004 : Consistently, GFRalpha1b promotes a stronger RET phosphorylation than GFRalpha1a
Coulpier et al., Mol Cell Neurosci 2004 : Retrograde signaling was associated with retrograde transport of radiolabeled GDNF and GFR alpha 1 , as well as activation of RET and AKT, but not of ERK1/2, in cell bodies
Jing et al., J Biol Chem 1997 : Both GFRalpha-1 and GFRalpha-2 mediate neurturin induced Ret phosphorylation