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PTK2 — SYK

Pathways - manually collected, often from reviews:

• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: Antigen/IgE/Fc epsilon R1/LYN/SYK complex (IGHE-SYK-LYN-MS4A2-FCER1G-FCER1A) → FAK (PTK2) (modification, activates) Bhattacharyya et al., Immunology 1999
  Evidence: assay, other species

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SYK — PTK2 (physical association, affinity chromatography technology) Chung et al., J Biol Chem 1997
• IRef Biogrid Interaction: SYK — PTK2 (physical association, affinity chromatography technology) Sada et al., Eur J Biochem 1997*
• IRef Hprd Interaction: PTK2 — SYK (in vivo) Chung et al., J Biol Chem 1997, Sada et al., Eur J Biochem 1997*
• IRef Intact Interaction: Complex of PTK2-SYK-MAL-SRC (association, anti bait coimmunoprecipitation) Honda et al., Nat Immunol 2012
• IRef Ophid Interaction: PTK2 — SYK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Shefler et al., J Immunol 2001 : However, in common with the FcepsilonRI mediated pathway, activation of Syk by c48/80 is dependent on a src-like protein tyrosine kinase
Takata et al., FEBS Lett 1995 : Kinase activity of Src-PTK was essential for tyrosine phosphorylation of Syk and calcium mobilization upon receptor ligation, whereas these events were not affected by the mutation of SH2 domain